Methyldopa Sesquihydrate
Suppliers
Names
[ CAS No. ]:
41372-08-1
[ Name ]:
Methyldopa Sesquihydrate
[Synonym ]:
a-Methyl-L-dopa
α-Methyl-L-dopa
Dopegyt
L-(-)-b-(3,4-Dihydroxyphenyl)-a-methylalanine
L-(-)-α-Methyl-β-(3,4-dihydroxyphenyl)alanine
L-(-)-a-Methyl-b-(3,4-dihydroxyphenyl)alanine
a-Methyl Dopa
L-α-Methyl-DOPA
α-Methyl dopa
EINECS 209-089-2
L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3)
Tyrosine, 3-hydroxy-α-methyl-, hydrate (1:1)
L-(a-Md)
L-α-Methyldopa
α-Methyldopa sesquihydrate
(-)-α-Methyldopa
3-Hydroxy-α-methyl-L-tyrosine
L-Tyrosine, 3-hydroxy-α-methyl-
Dopamet
(−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate
3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine,MK-351,Methyl-L-DOPA
(S)-(-)-a-Methyldopa
a-Methyl-b-(3,4-dihydroxyphenyl)-L-alanine
Bayer 1440L
Methyl dopa
Aldomet
(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-Alanine Sesquihydrate
l-a-Methyldopa
(S)-a-Methyldopa
ALDORIL
Alpha-Methyldopa Sesquihydrate
Alanine, 3- (3,4-dihydroxyphenyl)-2-methyl-, L-
MFCD00149280
Methyldopa
3-Hydroxy-α-methyltyrosine hydrate (1:1)
L-a-Methyl-3,4-dihydroxyphenylalanine
(-)-Methyldopa
Elanpres
L-Methyldopa
L-(-)-α-Methyldopa (hydrate)
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
441.6±45.0 °C at 760 mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C10H13NO4.3/2H2O
[ Molecular Weight ]:
238.24
[ Flash Point ]:
220.9±28.7 °C
[ PSA ]:
113.01000
[ LogP ]:
0.13
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.635
[ Storage condition ]:
Refrigerator
[ Stability ]:
Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.
[ Water Solubility ]:
0.1-1 g/100 mL at 23 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YP2860000
- CHEMICAL NAME :
- L-Tyrosine, 3-hydroxy-alpha-methyl-, sesquihydrate
- CAS REGISTRY NUMBER :
- 41372-08-1
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C10-H13-N-O4.3/2H2-O
- MOLECULAR WEIGHT :
- 238.27
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17500 mg/kg/14D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 68250 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - other changes
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 604 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2980 mg/kg
- SEX/DURATION :
- male 65 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Risk Phrases ]:
R20/21:Harmful by inhalation and in contact with skin . R36/37/38:Irritating to eyes, respiratory system and skin . R42/43:May cause sensitization by inhalation and skin contact . R65:Harmful: May cause lung damage if swallowed.
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YP2860000
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