LatanoprostAcid

Suppliers

Names

[ Name ]:
LatanoprostAcid

[Synonym ]:
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid
Latanoprost acid
latanoprost free acid
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)-
LatanoprostAcid
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
609.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₄O₅

[ Molecular Weight ]:
390.513

[ Flash Point ]:
336.2±26.6 °C

[ Exact Mass ]:
390.240631

[ PSA ]:
97.99000

[ LogP ]:
2.22

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Latanoprost
(4-Carboxybutyl)triphenylphosphonium bromide
Latanoprost Lactol
(-)-Corey lactone 4-phenylbenzoate alcohol
Benzyl bromide
[1,1'-Biphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-5-phenyl-1-pentenyl]-2H-cyclopenta[b]furan-5-yl ester
(1S,5R,6R,7R)-6-[(3S)-3-hydroxy-5-phenyl-1-pentenyl]-7-[(4-phenylbenzoyl)oxy]-2-oxabicyclo[3.3.0]octan-3-one

DownStream

Latanoprost
ACS67

Articles

New prostaglandin analog formulation for glaucoma treatment containing cyclodextrins for improved stability, solubility and ocular tolerance.

Eur. J. Pharm. Biopharm. 95 , 203-14, (2015)

Latanoprost is a practically insoluble prostaglandin F2α analog considered a first-line agent for glaucoma treatment. From a pharmaceutical point of view, latanoprost is challenging to be formulated a...

Effect of prostaglandins A(2), E(1), F(2 alpha)and latanoprost on cultured human iridal melanocytes.

Exp. Eye Res. 70(1) , 113-20, (2000)

The effect of various prostaglandins on the growth, melanogenesis and dendrification of cultured iridal melanocytes were studied. Iridal melanocytes were isolated and cultured with medium supplemented...

Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells.

Invest. Ophthalmol. Vis. Sci. 38(13) , 2772-80, (1997)

To identify matrix metalloproteinases (MMPs) released by ciliary smooth muscle cells in vitro and to determine whether MMP release is altered by exposure to prostaglandins (PGs).Human ciliary smooth m...

2-([(Benzyloxy)carbonyl](ethyl)amino)butanoic acid
4-(2-Aminopropan-2-yl)-1-methylpiperidin-4-ol
1-{[(Tert-butoxy)carbonyl](cyclopropyl)amino}cyclobutane-1-carboxylic acid
3-Amino-5-chloro-1-ethyl-2(1H)-pyridinone
2-((Tert-butoxycarbonyl)(isopropyl)amino)-2-methylpropanoic acid
3,3,4,4,4-Pentafluoro-2-methylbutanenitrile
2-{[(Tert-butoxy)carbonyl](propan-2-yl)amino}-2-phenylacetic acid
3,4,4,4-Tetrafluoro-2,2-dimethylbutan-1-amine
2-{[(Benzyloxy)carbonyl](propan-2-yl)amino}-2-methylpropanoic acid
2-(5,5-Dimethyl-3-oxo-1,2-oxazolidin-2-yl)acetic acid

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