Platinum,(1,2-ethanediamine-kN1,kN2)[propanedioato(2-)-kO1,kO3]-, (SP-4-2)-

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Names

[ CAS No. ]:
41666-77-7

[ Name ]:
Platinum,(1,2-ethanediamine-kN1,kN2)[propanedioato(2-)-kO1,kO3]-, (SP-4-2)-

[Synonym ]:
1,3-Cyclopentadiene,1-ethyl-,zirconium complex

Chemical & Physical Properties

[ Boiling Point ]:
386.8ºC at 760 mmHg

[ Molecular Formula ]:
C5H8N2O4Pt

[ Molecular Weight ]:
355.20600

[ Flash Point ]:
201.9ºC

[ Exact Mass ]:
355.01300

[ PSA ]:
76.66000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2505500
CHEMICAL NAME :
Platinum (II), (ethylenediammine)malonato-
CAS REGISTRY NUMBER :
41666-77-7
LAST UPDATED :
199509
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H10-N2-O4-Pt
MOLECULAR WEIGHT :
357.26
WISWESSER LINE NOTATION :
Z2Z &QV1VQ &-PT-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
1080 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,2148,1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BICHBX Bioinorganic Chemistry. (New York, NY) V.1-9, 1971-78. Volume(issue)/page/year: 2,187,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
107 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,2148,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
120 mg/kg/5D-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB80-217292

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • platinum ethylenediamine dichloride
  • Malonic acid
  • Platinum,(1,2-ethanediamine-kN1,kN2)diiodo-, (SP-4-2)-
  • malonic acid, barium salt

DownStream

Related Compounds

  • 8-Hydroxy-1-[(prop-2-en-1-yloxy)carbonyl]-decahydroquinoline-7-carboxylic acid
  • (1s,3s)-3-Hydroxy-3-{1-[(prop-2-en-1-yloxy)carbonyl]piperidin-4-yl}cyclobutane-1-carboxylic acid
  • 9-[(Prop-2-en-1-yloxy)carbonyl]-3-oxa-9-azaspiro[5.5]undecane-7-carboxylic acid
  • 2-{8-[(Prop-2-en-1-yloxy)carbonyl]-2-oxa-8-azaspiro[4.5]decan-3-yl}acetic acid
  • 1-{4-Hydroxy-1-[(prop-2-en-1-yloxy)carbonyl]piperidin-4-yl}cyclobutane-1-carboxylic acid
  • 4-[2-Chloro-4-(fluorosulfonyl)phenoxy]butanoic acid
  • rac-(2R,3S)-2-{1-[(prop-2-en-1-yloxy)carbonyl]piperidin-4-yl}oxolane-3-carboxylic acid
  • 8,8-Dimethyl-7-{[(prop-2-en-1-yloxy)carbonyl]amino}-2-oxabicyclo[4.2.0]octane-7-carboxylic acid
  • benzyl 6-(hydroxymethyl)-2,3-dihydro-1H-indole-1-carboxylate
  • benzyl N-(2-propanoylphenyl)carbamate
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