Tocainide
Suppliers
Names
[ CAS No. ]:
41708-72-9
[ Name ]:
Tocainide
[Synonym ]:
R/S-Tocainide
2-amino-2',6'-propionoxylidide
MFCD00072010
EINECS 255-505-0
TOCAINIDE
6'-propionoxylidide,2-amino-2
alanyl-2,6-xylidide
Chemical & Physical Properties
[ Molecular Formula ]:
C11H16N2O
[ Molecular Weight ]:
192.25800
[ Exact Mass ]:
192.12600
[ PSA ]:
55.12000
[ LogP ]:
2.36240
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UG6305000
- CHEMICAL NAME :
- 2',6'-Propionoxylidide, 2-amino-
- CAS REGISTRY NUMBER :
- 41708-72-9
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C11-H16-N2-O
- MOLECULAR WEIGHT :
- 192.29
- WISWESSER LINE NOTATION :
- ZY1&VMR B1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 229 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Cardiac - cardiomyopathy including infarction
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,760,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 5714 ug/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,141,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2606 mg/kg/11W-I
- TOXIC EFFECTS :
- Blood - aplastic anemia
- REFERENCE :
- NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 314,583,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 94 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - local anesthetic Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,1059,1981
Safety Information
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ HS Code ]:
2924299090
Synthetic Route
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%