Indicine N-oxide

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Names

[ CAS No. ]:
41708-76-3

[ Name ]:
Indicine N-oxide

[Synonym ]:
Indicine N-oxide

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₅NO₆

[ Molecular Weight ]:
315.36200

[ Exact Mass ]:
315.16800

[ PSA ]:
116.42000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7791200

CHEMICAL NAME :: Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H- pyrrolizin-7-yl)methyl ester, N-oxide, (1R-(1-apha,7(2R*,3S),7-a lpha,beta))-

CAS REGISTRY NUMBER :: 41708-76-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H25-N-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1917 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3733 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB84-161694

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GVRAAS Government Reports Announcements. (U.S.) (Washington, D.C.) V.71(6) -75(6), 1971-75. Merged with Government Reports Index (US) to form Government Reports Announcement Index (U.S.) Volume(issue)/page/year: 74(9),60,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 gm/kg/4W-I

TOXIC EFFECTS :: Blood - macrocytosis Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg/9D-I

TOXIC EFFECTS :: Blood - macrocytosis Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989

Safety Information

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, (1R-(1a,7(2R*,3S*),7a-beta))-
(1'S,2S,5R)-2-(t-butyl)-5-(1'hydroxyethyl)-5-isopropyl-1,3-dioxolan-4-one
Retronecine

DownStream

Related Compounds

Indicine N-oxide
Indicine N-oxide
(-)-indicine N-oxide
Camptothecin N-oxide
(1S,5R,13R,17S)-17-Hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one 4-oxide
Azithromycin N-Oxide
(3R,4S)-N,N,4-Trimethylpyrrolidin-3-amine hydrochloride
N-Methyl-2-(4,7,10-tris(2-(methylthio)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamide
tert-Butyl (S)-3-(oxazol-5-yl)piperidine-1-carboxylate
Methyl 5-hydroxy-4,6-dimethylnicotinate
rel-(4R,9AS)-2-benzyl-4-methyloctahydro-2H-pyrazino[1,2-a]pyrazine
Rel-(1R,6R)-3-oxabicyclo[4.1.0]heptane-7-carboxylic acid
Rel-(2R,4R)-4-hydroxytetrahydro-2H-pyran-2-carboxylic acid
(S)-1-(3-Bromophenyl)propane-1,3-diol
5,10,15,20-Tetraphenylporphyrinato ruthenium(II)
3-(2-Ethoxy-2-oxoethyl)imidazo[1,2-a]pyridine-6-carboxylic acid

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