1-Naphthalenol,2-amino-, hydrochloride (1:1)

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Names

[ CAS No. ]:
41772-23-0

[ Name ]:
1-Naphthalenol,2-amino-, hydrochloride (1:1)

[Synonym ]:
2-Amino-1-Naphthol Hydrochloride
MFCD00050530
2-aminonaphthalen-1-ol,hydrochloride
EINECS 255-548-5

Chemical & Physical Properties

[ Boiling Point ]:
343.5ºC at 760mmHg

[ Molecular Formula ]:
C10H10ClNO

[ Molecular Weight ]:
195.64500

[ Flash Point ]:
161.6ºC

[ Exact Mass ]:
195.04500

[ PSA ]:
46.25000

[ LogP ]:
3.51080

[ Index of Refraction ]:
1.741

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL3340000
CHEMICAL NAME :
1-Naphthol, 2-amino-, hydrochloride
CAS REGISTRY NUMBER :
41772-23-0
LAST UPDATED :
199710
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C10-H9-N-O.Cl-H
MOLECULAR WEIGHT :
195.66
WISWESSER LINE NOTATION :
L66J BQ CZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg/45W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 6,412,1952
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg/45W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 6,412,1952
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 17,127,1963
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 10,539,1956
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,286,1951
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 6,412,1952 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38-40

[ Safety Phrases ]:
S26-S36/37/39

[ RTECS ]:
QL3340000

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2Z)-2-hydroxyiminotetralin-1-one
  • 3,4-Dihydronaphthalen-1(2H)-one

DownStream

  • 2-diazonionaphthalen-1-olate

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 1-Naphthalenol,2-[(dimethylamino)methyl]-, hydrochloride (1:1)
  • 1-Naphthalenol,2-(1-aminoethyl)-, hydrochloride (1:1)
  • 1-Naphthalenol, 2-amino-1,2,3,4-tetrahydro-6-methoxy
  • 1-Naphthalenol, 2-amino-6-fluoro-1,2,3,4-tetrahydro
  • 1-Naphthalenol, 2-amino-6,8-difluoro-1,2,3,4-tetrahydro
  • 1-Naphthalenol, 2-amino-1,2,3,4-tetrahydro-8-methoxy
  • 1-O'-tert-butyl 1-O-ethyl cyclobutane-1,1-dicarboxylate
  • (2R,4aR,6R,7S,8R,8aR)-8-(2-Naphthylmethoxy)-2-phenyl-6-(p-tolylthio)hexahydropyrano[3,2-d][1,3]dioxin-7-ol
  • TC-2216 trihydrochloride
  • 2-(4-((2-Methoxyethyl)thio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • methyl 2-(5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-methylpropanoate
  • (2S)-N-(1H-1,3-benzodiazol-1-yl)-1-(prop-2-yn-1-yl)pyrrolidine-2-carboxamide
  • Phenethylboronic acid MIDA ester
  • Potassium tetracyanopalladate(II) xhydrate
  • 2-Allyl-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
  • 2-(4-Benzylpiperazin-1-yl)-1-phenylethanone;hydrobromide
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