2-Aza-8-germaspiro[4.5]decane-2-propanamine,8,8-diethyl-N,N-dimethyl-, hydrochloride (1:2)
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Names
[ CAS No. ]:
41992-22-7
[ Name ]:
2-Aza-8-germaspiro[4.5]decane-2-propanamine,8,8-diethyl-N,N-dimethyl-, hydrochloride (1:2)
[Synonym ]:
Spirogermanium hydrochloride
Spirogermanium dihydrochloride
2-Aza-8-germaspiro(4.5)decane-2-propanamine,8,8-diethyl-N,N-dimethyl-,dihydrochloride
Spiro-32
8,8-Diethyl-N,N-dimethyl-2-aza-8-germaspiro(4.5)decane-2-propanamine dihydrochloride
Spirogermanium hydrochloride (USAN)
Chemical & Physical Properties
[ Boiling Point ]:
382.8ºC at 760mmHg
[ Molecular Formula ]:
C17H37ClGeN2
[ Molecular Weight ]:
377.58200
[ Flash Point ]:
165.8ºC
[ Exact Mass ]:
378.18600
[ PSA ]:
6.48000
[ LogP ]:
4.65250
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CL7618500
- CHEMICAL NAME :
- 2-Aza-8-germaspiro(4.5)decane-2-propanamine, 8,8-diethyl-N,N-dimethyl, dihydrochloride
- CAS REGISTRY NUMBER :
- 41992-22-7
- LAST UPDATED :
- 198605
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C17-H36-Ge-N2.2Cl-H
- MOLECULAR WEIGHT :
- 414.06
- WISWESSER LINE NOTATION :
- T6-GE- DXTJ A2 A2 D-& CT5N CXTJ A3N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB264-117
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 119 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Blood - hemorrhage Blood - other changes
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980