Fenofibric acid

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Names

[ CAS No. ]:
42017-89-0

[ Name ]:
Fenofibric acid

[Synonym ]:
Procetofenic acid
2-(4'-(p-chlorobenzoyl)phenoxy)-2-methylpropionic acid
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic acid
Fibricor
Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-
Fenofibric acid
Fenofibrate Related Compound B
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid
Fenofibrate impurity B
EINECS 255-626-9
MFCD00792461
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
486.5±35.0 °C at 760 mmHg

[ Melting Point ]:
176--179ºC

[ Molecular Formula ]:
C₁₇H₁₅ClO₄

[ Molecular Weight ]:
318.752

[ Flash Point ]:
248.0±25.9 °C

[ Exact Mass ]:
318.065887

[ PSA ]:
63.60000

[ LogP ]:
3.86

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA2453000

CHEMICAL NAME :: Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-

CAS REGISTRY NUMBER :: 42017-89-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H15-Cl-O4

MOLECULAR WEIGHT :: 318.77

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1242 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,229,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 313 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - pleural thickening

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 23(Suppl 4),S873,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,885,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,885,1976

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
UN 3077 9 / PGIII

[ RTECS ]:
UA2453000

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

benzyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
Chloroform
4-p-Chlorobenzoylphenol
Acetone
2-Bromo-2-methylpropionic acid
Fenofibrate
4-Chlorobenzoyl chloride
Anisole

DownStream

Fenofibrate
Choline Fenofibrate
propan-2-yl 2-[4-[(4-chlorophenyl)-hydroxymethyl]phenoxy]-2-methylpropanoate
2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoyl chloride

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.

Biochim. Biophys. Acta 1851(2) , 231-7, (2015)

X-linked adrenoleukodystrophy (X-ALD) is a neurometabolic disease that is caused by mutations in the ABCD1 gene. ABCD1 protein deficiency impairs peroxisomal very long-chain fatty acid (VLCFA) degrada...

The Lidose hard capsule formulation of fenofibrate is suprabioavailable compared to the nanoparticle tablet formulation under high-fat fed conditions.

J. Pharm. Pharm. Sci. 18(1) , 61-7, (2015)

The therapeutic equivalence of multiple registered fenofibrate formulations, several of which are suprabioavailable and therefore marketed at lower dosage strengths than their reference products, is b...

Endoplasmic reticulum stress involved in high-fat diet and palmitic acid-induced vascular damages and fenofibrate intervention.

Biochem. Biophys. Res. Commun. 458(1) , 1-7, (2015)

Fenofibrate (FF) is widely used to lower blood lipids in clinical practice, but whether its protective effect on endothelium-dependent vasodilatation (EDV) in thoracic aorta is related with endoplasmi...

fenofibric acid
Fenofibric acid-d6
fenofibric acid chloride
2-Chloro Fenofibric Acid
3-Chloro Fenofibric Acid
Fenofibric acid ethyl ester
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2-((5H-pyrimido[5,4-b]indol-4-yl)thio)-1-(4-(4-fluorophenyl)piperazin-1-yl)ethanone
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