Pumitepa

Names

[ CAS No. ]:
42061-52-9

[ Name ]:
Pumitepa

[Synonym ]:
<32P>-Fopunic
6-Diethylenimidophosphoamido-2-dimethylamino-7-methylpurin
bis-aziridin-1-yl-phosphinic acid 2-dimethylamino-7-methyl-7H-purin-6-ylamide
Bis(1-aziridinyl)[[2-(dimethylamino)-7-methyl-7H-purin-6-yl]amino]phosphine oxide

Chemical & Physical Properties

[ Density]:
1.7g/cm3

[ Boiling Point ]:
528.7ºC at 760mmHg

[ Molecular Formula ]:
C12H19N8OP

[ Molecular Weight ]:
322.30600

[ Flash Point ]:
273.5ºC

[ Exact Mass ]:
322.14200

[ PSA ]:
91.77000

[ LogP ]:
0.52930

[ Index of Refraction ]:
1.828

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ5827000
CHEMICAL NAME :
Phosphinic amide, P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7 H-purin-6-yl)-
CAS REGISTRY NUMBER :
42061-52-9
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C12-H19-N8-O-P
MOLECULAR WEIGHT :
322.36
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ B1 GN1&1 IMPO&- AT3NTJ&- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
24 mg/kg
REFERENCE :
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 102(7),76,1986

Related Compounds

  • 2-[5-Fluoro-2-(trifluoromethyl)phenyl]-2-methoxypropan-1-amine
  • 3-{4-[(Trifluoromethyl)sulfanyl]phenyl}oxolane-2,5-dione
  • 1-(3-Bromo-5-chlorophenyl)ethane-1,2-diol
  • 3-(2,5-Dihydroxyphenyl)-2-hydroxy-2-methylpropanoic acid
  • 2-Amino-3-(3-fluoropyridin-4-yl)-2-methylpropan-1-ol
  • 5-chloro-4-(2-isocyanatoethyl)-1,3-dimethyl-1H-pyrazole
  • 1-{[(5-Chloroquinolin-8-yl)oxy]methyl}cyclohexan-1-ol
  • Methyl 3-(4-cyclopropyl-1,3-thiazol-5-yl)-2-hydroxypropanoate
  • 1-(Bromomethyl)-1-(2,2,3,3-tetrafluoropropyl)cyclopropane
  • 2,2-Dimethoxyethyl sulfamate
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