Pumitepa

Names

[ CAS No. ]:
42061-52-9

[ Name ]:
Pumitepa

[Synonym ]:
<32P>-Fopunic
6-Diethylenimidophosphoamido-2-dimethylamino-7-methylpurin
bis-aziridin-1-yl-phosphinic acid 2-dimethylamino-7-methyl-7H-purin-6-ylamide
Bis(1-aziridinyl)[[2-(dimethylamino)-7-methyl-7H-purin-6-yl]amino]phosphine oxide

Chemical & Physical Properties

[ Density]:
1.7g/cm3

[ Boiling Point ]:
528.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₉N₈OP

[ Molecular Weight ]:
322.30600

[ Flash Point ]:
273.5ºC

[ Exact Mass ]:
322.14200

[ PSA ]:
91.77000

[ LogP ]:
0.52930

[ Index of Refraction ]:
1.828

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ5827000

CHEMICAL NAME :: Phosphinic amide, P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7 H-purin-6-yl)-

CAS REGISTRY NUMBER :: 42061-52-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C12-H19-N8-O-P

MOLECULAR WEIGHT :: 322.36

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ B1 GN1&1 IMPO&- AT3NTJ&- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

REFERENCE :: BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 102(7),76,1986

Related Compounds

2-(4-Bromo-3-nitro-phenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene
2-(4-Bromo-2-nitro-phenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene
2-(3-Bromo-5-nitro-phenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene
2-(2-Bromo-6-nitro-phenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene
2-(2-Bromo-5-nitro-phenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene
2-(4-Bromo-2-chloro-6-nitro-phenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene
1,3-Difluoro-2-(5-iodo-2-nitro-phenoxy)-5-(trifluoromethyl)benzene
1,3-Difluoro-2-(4-iodo-2-nitro-phenoxy)-5-(trifluoromethyl)benzene
5-[2,6-Difluoro-4-(trifluoromethyl)phenoxy]-2,4-Difluoroaniline
4-[2,6-Difluoro-4-(trifluoromethyl)phenoxy]-3,5-Difluoroaniline

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