Pumitepa

Names

[ CAS No. ]:
42061-52-9

[ Name ]:
Pumitepa

[Synonym ]:
<32P>-Fopunic
6-Diethylenimidophosphoamido-2-dimethylamino-7-methylpurin
bis-aziridin-1-yl-phosphinic acid 2-dimethylamino-7-methyl-7H-purin-6-ylamide
Bis(1-aziridinyl)[[2-(dimethylamino)-7-methyl-7H-purin-6-yl]amino]phosphine oxide

Chemical & Physical Properties

[ Density]:
1.7g/cm3

[ Boiling Point ]:
528.7ºC at 760mmHg

[ Molecular Formula ]:
C12H19N8OP

[ Molecular Weight ]:
322.30600

[ Flash Point ]:
273.5ºC

[ Exact Mass ]:
322.14200

[ PSA ]:
91.77000

[ LogP ]:
0.52930

[ Index of Refraction ]:
1.828

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ5827000
CHEMICAL NAME :
Phosphinic amide, P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7 H-purin-6-yl)-
CAS REGISTRY NUMBER :
42061-52-9
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C12-H19-N8-O-P
MOLECULAR WEIGHT :
322.36
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ B1 GN1&1 IMPO&- AT3NTJ&- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
24 mg/kg
REFERENCE :
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 102(7),76,1986

Related Compounds

  • 1-[3-amino-3-(trimethyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]-2,2,2-trifluoroethan-1-one
  • 1-[3-amino-3-(1-methyl-1H-imidazol-5-yl)pyrrolidin-1-yl]-2,2,2-trifluoroethan-1-one
  • tert-butyl N-[3-(1-methyl-1H-pyrazol-3-yl)piperidin-3-yl]carbamate
  • 2-{1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]pyrrolidin-3-yl}acetic acid
  • 3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-enamido]-4-iodobenzoic acid
  • 4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(4-methylthiophen-3-yl)carbamoyl]butanoic acid
  • (3R)-3-{[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyridin-2-yl]formamido}pentanoic acid
  • 3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethyl-N-propylbutanamido]propanoic acid
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1-methyl-1H-1,2,3-triazol-5-yl)cyclobutane-1-carboxylic acid
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1-methyl-1H-1,2,3-triazol-4-yl)cyclobutane-1-carboxylic acid
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