Quinacrine mustard dihydrochloride

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Names

[ Name ]:
Quinacrine mustard dihydrochloride

[Synonym ]:
Quinacrine mustard dihydrochloride
N4,N4-Bis-(2-chlor-aethyl)-N1-(6-chlor-2-methoxy-acridin-9-yl)-1-methyl-butandiyldiamin,Dihydrochlorid
N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine dihydrochloride
EINECS 224-140-9
N4,N4-bis-(2-chloro-ethyl)-N1-(6-chloro-2-methoxy-acridin-9-yl)-1-methyl-butanediyldiamine,dihydrochloride
quinacrine mustard
Atabrine mustard dihydrochloride
ICR 10
3-chloro-7-methoxy-9-(1-methyl-4-(N,N-bis(2-chloroethyl)amino)butylamino)acridine dihydrochloride
1-N,1-N-bis(2-chloroethyl)-4-N-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine,dihydrochloride
Mepacrine mustard dihydrochloride

Chemical & Physical Properties

[ Density]:
1.271g/cm3

[ Boiling Point ]:
574.1ºC at 760 mmHg

[ Melting Point ]:
150 °C

[ Molecular Formula ]:
C₂₃H₃₀Cl₅N₃O

[ Molecular Weight ]:
541.76900

[ Flash Point ]:
301ºC

[ Exact Mass ]:
539.08300

[ PSA ]:
37.39000

[ LogP ]:
8.08720

[ Index of Refraction ]:
1.632

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7580000

CHEMICAL NAME :: Acridine, 9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-ch loro-2-methoxy-, dihydrochloride

CAS REGISTRY NUMBER :: 4213-45-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C23-H28-Cl3-N3-O.2Cl-H

MOLECULAR WEIGHT :: 541.81

WISWESSER LINE NOTATION :: T C666 BNJ EG IMY3N2G2G LO1 &GH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 ug/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 50 umol/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,553,1974

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317-H331-H334-H361

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
46-23/25-42/43

[ RIDADR ]:
UN 3249

[ RTECS ]:
AR7580000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.

J. Biol. Chem. 280(9) , 7614-23, (2005)

Tau protein is the major component of the intraneuronal filamentous inclusions that constitute defining neuropathological characteristics of Alzheimer's disease and other tauopathies. The discovery of...

Molecular cytogenetic analysis of the highly repetitive DNA in the genome of Apodemus argenteus, with comments on the phylogenetic relationships in the genus Apodemus.

Cytogenet. Cell Genet. 92(3-4) , 254-63, (2001)

The DNA of Apodemus argenteus was digested with DraI, and the resultant DraI fragment of highly repetitive DNA was isolated and analyzed by DNA filter hybridization, cloning, sequencing, and fluoresce...

Separation of sperm through a 12-layer percoll column decreases the percentage of sperm staining with quinacrine.

Arch. Androl. 44(1) , 47-50, (2000)

Previous methods of enriching sperm with a higher percentage of Y-bearing sperm have been questioned because the claims that Y enrichment was present were based on quinacrine staining of the Y chromos...