Oxilorphan
Names
[ CAS No. ]:
42281-59-4
[ Name ]:
Oxilorphan
[Synonym ]:
(L)-BC-2605
Oxilorfano [INN-Spanish]
Levo-BC-2605
Bristol laboratories BC 2605
(-)-17-Cyclopropylmethylmorphinan-3,4-diol
3,14-dihydroxy-N-cyclopropylmethylmorphinan
EINECS 255-749-8
Chemical & Physical Properties
[ Density]:
1.27g/cm3
[ Boiling Point ]:
495.4ºC at 760mmHg
[ Molecular Formula ]:
C20H27NO2
[ Molecular Weight ]:
313.43400
[ Flash Point ]:
262.9ºC
[ Exact Mass ]:
313.20400
[ PSA ]:
43.70000
[ LogP ]:
2.91340
[ Index of Refraction ]:
1.653
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QC7800000
- CHEMICAL NAME :
- Morphinan-3,14-diol, 17-(cyclopropylmethyl)-
- CAS REGISTRY NUMBER :
- 42281-59-4
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H27-N-O2
- MOLECULAR WEIGHT :
- 313.48
- WISWESSER LINE NOTATION :
- T6 G666/FQ 2AF Q FX ONT&TTJ AQ IQ O1- AL3TJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 14 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes
- REFERENCE :
- JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 16,183,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 26 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,746,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 315 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975