Oxilorphan

Names

[ Name ]:
Oxilorphan

[Synonym ]:
(L)-BC-2605
Oxilorfano [INN-Spanish]
Levo-BC-2605
Bristol laboratories BC 2605
(-)-17-Cyclopropylmethylmorphinan-3,4-diol
3,14-dihydroxy-N-cyclopropylmethylmorphinan
EINECS 255-749-8

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
495.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₇NO₂

[ Molecular Weight ]:
313.43400

[ Flash Point ]:
262.9ºC

[ Exact Mass ]:
313.20400

[ PSA ]:
43.70000

[ LogP ]:
2.91340

[ Index of Refraction ]:
1.653

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QC7800000

CHEMICAL NAME :: Morphinan-3,14-diol, 17-(cyclopropylmethyl)-

CAS REGISTRY NUMBER :: 42281-59-4

LAST UPDATED :: 199009

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H27-N-O2

MOLECULAR WEIGHT :: 313.48

WISWESSER LINE NOTATION :: T6 G666/FQ 2AF Q FX ONT&TTJ AQ IQ O1- AL3TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 14 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes

REFERENCE :: JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 16,183,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 26 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,746,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975

Related Compounds

7-[(2-fluorophenyl)methyl]-8-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-1,3-dimethyl-5H-purin-7-ium-2,6-dione
(5,7-Dimethyl-4,6-dioxo-2-phenyl-5,7,9-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(17),9,11,13,15-pentaen-17-yl) propanoate
7-benzyl-8-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-1,3-dimethyl-4,5-dihydropurine-2,6-dione
6-[(4-Methylphenyl)sulfanylmethyl]-2-morpholin-4-yl-1,3-diazinan-4-one
7-chloro-2-(furan-2-ylmethyl)-1-pyridin-3-yl-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
2-(2-hydroxyethyl)-1-(3-hydroxyphenyl)-6,8-dimethyl-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
6-[(4-Chlorophenyl)sulfanylmethyl]-2-piperidin-1-yl-1,3-diazinan-4-one
1,3,8,8-Tetramethyl-5-(2-prop-2-enoxyphenyl)-7,9-dihydropyrimido[4,5-b]quinolin-10-ium-2,4,6-trione
6-Methyl-2-(4-methylpiperazin-1-yl)-5-(naphthalen-1-ylmethyl)-1,3-diazinan-4-one
6-(4-methoxyphenyl)-4-methyl-2-(2-morpholin-4-ylethyl)-8,9a-dihydro-7H-purino[7,8-a]imidazol-9-ium-1,3-dione

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.