Nimustine Hydrochloride

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Names

[ CAS No. ]:
42471-28-3

[ Name ]:
Nimustine Hydrochloride

[Synonym ]:
EINECS 255-838-1
NIMUSTINE
1-(2-chloroethyl)-1-nitroso-3-[(2-methyl-4-aminopyrimidine-5-yl)methyl]urea
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea
3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-1-(2-chloro-ethyl)-1-nitroso-urea
MFCD01676942
Nimustina
Nimustin
Nimustinum [INN-Latin]
1-(2-chloro-ethyl)-3-(4-amino-2-methyl-5-pyrimidinyl)methyl-1-nitrosourea
Nimustina [INN-Spanish]
Nimustine [INN]
Nimustinum

Chemical & Physical Properties

[ Density]:
1.52g/cm3

[ Molecular Formula ]:
C9H13ClN6O2

[ Molecular Weight ]:
272.69200

[ Exact Mass ]:
272.07900

[ PSA ]:
113.57000

[ LogP ]:
1.77110

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YR8449000
CHEMICAL NAME :
Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chlo roethyl)-N-nitroso-
CAS REGISTRY NUMBER :
42471-28-3
BEILSTEIN REFERENCE NO. :
0685903
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C9-H13-Cl-N6-O2
MOLECULAR WEIGHT :
272.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
3 mg/kg
SEX/DURATION :
multigeneration
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - rat Cells - not otherwise specified
DOSE/DURATION :
2 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,95,1985

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
YR8450000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Urea,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N'-(2-chloroethyl)-

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Nimustine Hydrochloride
  • nimustine hydrochloride
  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • Elacridar hydrochloride
  • (3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(3,4,5-trifluorophenyl)propanoic acid
  • (3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(furan-3-yl)propanoic acid
  • (3S)-3-(4-chloro-3-fluorophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • 3-(2,5-dimethylthiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • (R)-3-(4-Tert-butyl-phenyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid
  • 3-(5-ethylfuran-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • (3R)-3-(5-ethylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • (3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(3-fluoro-4-methylphenyl)propanoic acid
  • (3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(pyrimidin-4-yl)propanoic acid
  • (3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(quinolin-6-yl)propanoic acid
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