[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

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Names

[ CAS No. ]:
425-51-4

[ Name ]:
[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

[Synonym ]:
6,7-Dehydro-17Alpha-acetoxy Progesterone
17-Hydroxypregna-4,6-diene-3,20-dione acetate
6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione
Melengestro acetate
17-acetoxy-pregna-4,6-diene-3,20-dione
Megestil

Chemical & Physical Properties

[ Density]:
1.16g/cm3

[ Boiling Point ]:
504.7ºC at 760mmHg

[ Molecular Formula ]:
C23H30O4

[ Molecular Weight ]:
370.48200

[ Flash Point ]:
218.7ºC

[ Exact Mass ]:
370.21400

[ PSA ]:
60.44000

[ LogP ]:
4.18520

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4067000
CHEMICAL NAME :
Pregna-4,6-diene-3,20-dione, 17-hydroxy-, acetate (ester)
CAS REGISTRY NUMBER :
425-51-4
LAST UPDATED :
198910
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C23-H30-O4
MOLECULAR WEIGHT :
370.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
25 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
25 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,3,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • 17-(Acetyloxy)-3-Methoxy-pregna-3,5-dien-20-one

DownStream

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-(8-(4-ethoxyphenyl)-3,4-dioxo-3,4,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-2(6H)-yl)-N-phenethylacetamide
  • 3-Cyclohexene-1-carboxylic acid, 2,2,2-trifluoroethyl ester, (1S)-
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-(3,5-dimethylphenyl)-4-(3-methylbenzyl)-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • Bis[heptafluoro-1,1-bis(trifluoromethyl)butyl] trisulfide
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 3-Acetyl-N-isopropylbenzamide
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol