Methyl 6-chloro-2-methyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzoth iadiazine-3-carboxylate 1,1-dioxide

Names

[ CAS No. ]:
42583-55-1

[ Name ]:
Methyl 6-chloro-2-methyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzoth iadiazine-3-carboxylate 1,1-dioxide

[Synonym ]:
carmetizide
3.8-Dinitro-6-chlor-phenanthridin
6-chloro-3,8-dinitro-phenanthridine
6-Chlor-3,8-dinitro-phenanthridin
6-Chlor-3.4-dihydro-3-methoxycarbonyl-2-methyl-7-sulfamoyl-2H-1.2.4-benzothiadiazin-1.1-dioxid

Chemical & Physical Properties

[ Density]:
1.618g/cm3

[ Boiling Point ]:
589.4ºC at 760mmHg

[ Molecular Formula ]:
C10H12ClN3O6S2

[ Molecular Weight ]:
369.80200

[ Flash Point ]:
310.3ºC

[ Exact Mass ]:
368.98600

[ PSA ]:
152.63000

[ LogP ]:
2.47030

[ Index of Refraction ]:
1.605

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK8180000
CHEMICAL NAME :
2H-1,2,4-Benzothiadiazine-3-carboxylic acid, 7-(aminosulfonyl)-6-chloro-3,4-dihydro- 2-methyl-, methyl ester, 1,1-dioxide
CAS REGISTRY NUMBER :
42583-55-1
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C10-H12-Cl-N3-O6-S2
MOLECULAR WEIGHT :
369.82
WISWESSER LINE NOTATION :
T66 BSWN EM DHJ C1 DVO1 HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • Tert-butyl 3-(aminomethyl)cyclobutane-1-carboxylate
  • 1-(1-Bromoethyl)-3,5-dichloro-2-fluorobenzene
  • [5-Cyclopropyl-4-(2-methylpropyl)-1,2-oxazol-3-yl]methanol
  • Tert-butyl 4-[(6-oxo-1H-pyridine-3-carbonyl)amino]benzoate
  • (3,3-Dimethyl-2-oxabicyclo[2.2.1]heptan-1-yl)methanol
  • 2-Propan-2-yl-1,2,4-triazole-3-sulfonyl fluoride
  • 8-(2-Bromoethyl)spiro[2.5]octane
  • 6,6-Dimethyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid
  • 4-(2,2-Dimethyl-3-oxocyclobutyl)benzoic acid
  • Propan-2-yl 5-chloro-2-(trifluoromethyl)pyrimidine-4-carboxylate
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