Methyl 6-chloro-2-methyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzoth iadiazine-3-carboxylate 1,1-dioxide

Names

[ CAS No. ]:
42583-55-1

[ Name ]:
Methyl 6-chloro-2-methyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzoth iadiazine-3-carboxylate 1,1-dioxide

[Synonym ]:
carmetizide
3.8-Dinitro-6-chlor-phenanthridin
6-chloro-3,8-dinitro-phenanthridine
6-Chlor-3,8-dinitro-phenanthridin
6-Chlor-3.4-dihydro-3-methoxycarbonyl-2-methyl-7-sulfamoyl-2H-1.2.4-benzothiadiazin-1.1-dioxid

Chemical & Physical Properties

[ Density]:
1.618g/cm3

[ Boiling Point ]:
589.4ºC at 760mmHg

[ Molecular Formula ]:
C10H12ClN3O6S2

[ Molecular Weight ]:
369.80200

[ Flash Point ]:
310.3ºC

[ Exact Mass ]:
368.98600

[ PSA ]:
152.63000

[ LogP ]:
2.47030

[ Index of Refraction ]:
1.605

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK8180000
CHEMICAL NAME :
2H-1,2,4-Benzothiadiazine-3-carboxylic acid, 7-(aminosulfonyl)-6-chloro-3,4-dihydro- 2-methyl-, methyl ester, 1,1-dioxide
CAS REGISTRY NUMBER :
42583-55-1
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C10-H12-Cl-N3-O6-S2
MOLECULAR WEIGHT :
369.82
WISWESSER LINE NOTATION :
T66 BSWN EM DHJ C1 DVO1 HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • benzyl N-[5-bromo-3-(1,1,2,2,2-pentafluoroethyl)pyridin-2-yl]carbamate
  • benzyl 2-(4-iodo-1-methyl-1H-pyrazol-3-yl)piperidine-1-carboxylate
  • benzyl N-[(4-bromophenyl)(pyridin-3-yl)methyl]-N-ethylcarbamate
  • Tert-butyl 4-[(5-bromothiophen-2-yl)sulfonyl]-1,4-diazepane-1-carboxylate
  • benzyl N-(3,5-dibromo-6-cyclopropylpyridin-2-yl)carbamate
  • Methyl 3-{[(benzyloxy)carbonyl]amino}-4-bromo-5-tert-butylthiophene-2-carboxylate
  • tert-butyl N-{[1-(4-bromophenyl)pyrrolidin-3-yl]methyl}carbamate
  • tert-butyl N-[(1R)-2,2,2-trifluoro-1-[2-fluoro-4-(2-fluoroethoxy)phenyl]ethyl]carbamate
  • benzyl N-{2-hydroxy-1-[2-(trifluoromethoxy)phenyl]ethyl}carbamate
  • benzyl N-{2-hydroxy-2-[3-(trifluoromethoxy)phenyl]ethyl}carbamate
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