TAK-700 (Orteronel)

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Names

[ CAS No. ]:
426219-18-3

[ Name ]:
TAK-700 (Orteronel)

[Synonym ]:
6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide
S1195_Selleck
2-Naphthalenecarboxamide, 6-(6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-
TAK700
(S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-e]imidazol-7-yl)-N-methyl-2-naphthamide
TAK-700 (Orteronel)
6-[7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthamide
Orteronel
TAK-700

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
685.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H17N3O2

[ Molecular Weight ]:
307.346

[ Flash Point ]:
368.2±28.7 °C

[ Exact Mass ]:
307.132080

[ PSA ]:
67.15000

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.695

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-[1,3-dihydroxy-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide
  • methylamine
  • 6-Bromo-N-methyl-2-naphthamide
  • 5H-PYRROLO[1,2-C]IMIDAZOL-7(6H)-ONE
  • n-Butyllithium
  • 6-Bromo-2-naphthoic acid
  • 6-bromo-N,N-diisopropyl-2-naphthamide
  • N,N-diisopropyl-6-[1-hydroxy-1-(1-trityl-1H-imidazol-4-yl)methyl]-2-naphthamide
  • N,N-diisopropyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide

DownStream

  • Orteronel
  • 6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

Related Compounds

  • TAK-700
  • Orteronel
  • 6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide
  • TAK-802 hydrochloride
  • TAK-020
  • TAK-960
  • N-((4-(dimethylamino)-6-methylpyrimidin-2-yl)methyl)-4-ethoxybenzamide
  • benzyl N-(1-cyanocyclobutyl)carbamate
  • (7-(2-Chlorophenyl)-1,4-thiazepan-4-yl)(isoxazol-5-yl)methanone
  • N-((4-(dimethylamino)pyrimidin-2-yl)methyl)-2,6-difluorobenzamide
  • 1-(7-(2-chlorophenyl)-1,4-thiazepan-4-yl)-2-(1H-indol-1-yl)ethanone
  • 5-Thiomorpholinopent-3-YN-1-OL
  • 4-[3-(5-Methyloxolan-2-YL)propanoyl]morpholine-3-carbonitrile
  • 4-[1-Methyl-5-(trifluoromethyl)indole-2-carbonyl]morpholine-3-carbonitrile
  • 4-(2,3-Dihydro-1-benzothiophene-3-carbonyl)morpholine-3-carbonitrile
  • 1-(7-(2-Chlorophenyl)-1,4-thiazepan-4-yl)-2-(cyclopentylthio)ethanone
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