tlck

Suppliers

Names

[ Name ]:
tlck

[Synonym ]:
MFCD00065395
EINECS 224-266-4
Benzenesulfonamide, N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-, hydrochloride (1:1)
N-[(3S)-7-Amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide hydrochloride (1:1)
Tosyllysine chloromethyl ketone (hydrochloride)
N-[(3S)-7-Amino-1-chloro-2-oxo-3-heptanyl]-4-methylbenzenesulfonamide hydrochloride (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
509.8ºC at 760 mmHg

[ Melting Point ]:
-165ºC (dec.)

[ Molecular Formula ]:
C₁₄H₂₂Cl₂N₂O₃S

[ Molecular Weight ]:
369.307

[ Flash Point ]:
262.1ºC

[ Exact Mass ]:
368.072815

[ PSA ]:
97.64000

[ LogP ]:
4.55280

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT5160000

CHEMICAL NAME :: p-Toluenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-, hydrochloride, L-

CAS REGISTRY NUMBER :: 4272-74-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H21-Cl-N2-O3-S.Cl-H

MOLECULAR WEIGHT :: 369.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 150 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 19,95,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 3335

[ WGK Germany ]:
3

[ RTECS ]:
XT5160000

[ HS Code ]:
29350090

Articles

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

Antimicrob. Agents Chemother. 58(7) , 3666-78, (2014)

Therapies to prevent transmission of malaria parasites to the mosquito vector are a vital part of the global malaria elimination agenda. Primaquine is currently the only drug with such activity; howev...

TLCK
tlck
TLCK
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