6-Methoxy-1,2,3,4-tetrahydroisochinolin

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Names

[ CAS No. ]:
42923-77-3

[ Name ]:
6-Methoxy-1,2,3,4-tetrahydroisochinolin

[Synonym ]:
6-methoxy-1,2,3,4-tetrahydroisoquinoline
6-Methoxy-1,2,3,4-tetrahydroisochinolin

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
283.6±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H13NO

[ Molecular Weight ]:
163.216

[ Flash Point ]:
109.2±16.8 °C

[ Exact Mass ]:
163.099716

[ PSA ]:
21.26000

[ LogP ]:
1.32

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.532

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX5082000
CHEMICAL NAME :
Isoquinoline, 1,2,3,4-tetrahydro-6-methoxy-
CAS REGISTRY NUMBER :
42923-77-3
BEILSTEIN REFERENCE NO. :
0131274
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H13-N-O
MOLECULAR WEIGHT :
163.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - central sympatholytic
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,244,1948

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-51

[ RTECS ]:
NX5082000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-Methoxy-3,4-dihydro-1(2H)-isoquinolinone
  • Formaldehyde
  • 3-Methoxy-2-phenylethylamine
  • 6-methoxy-3,4-dihydro-isoquinoline
  • 2-(3-methoxyphenyl)-N-methyleneethanamine
  • 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
  • 6-Methoxyisoquinoline
  • N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine
  • m-Anisaldehyde

DownStream

  • 6-Methoxyisoquinoline
  • 4-Methoxyphthalic acid
  • 4-Methoxyphthalimide
  • 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
  • 1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobrimide
  • 1,2,3,4-Tetrahydro-6-isoquinolinol
  • tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
  • ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate
  • tert-butyl 7-amino-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 6-Methoxy-1,2,3,4-tetrahydroisochinolinhydrochlorid
  • 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carbaldehyde
  • 6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol
  • 6-METHOXY-1,2,3,4-TETRAHYDRO-9 H-PYRIDO[3,4-B]INDOLE HYDROCHLORIDE
  • 6-methoxy-1,2,3,4-tetraphenylnaphthalene
  • 6-methoxy-1,2,3,4-tetrahydroisoquinoline-4,7-diol,hydrochloride