3-Hydroxy-pyrrolidine-2-carboxylic acid

Names

[ Name ]:
3-Hydroxy-pyrrolidine-2-carboxylic acid

[Synonym ]:
tert-butyl cis-3-hydroxycyclobutanecarboxylate
cis-3-hydroxy-cyclobutanecarboxylic acid tert-butyl ester
MFCD00143991
cis-tert-Butyl 3-hydroxycyclobutanecarboxylate

Chemical & Physical Properties

[ Density]:
1.395g/cm3

[ Boiling Point ]:
355.233ºC at 760 mmHg

[ Melting Point ]:
232ºC (dec.)(lit.)

[ Molecular Formula ]:
C₅H₉NO₃

[ Molecular Weight ]:
131.13000

[ Flash Point ]:
168.639ºC

[ Exact Mass ]:
131.05800

[ PSA ]:
69.56000

[ Index of Refraction ]:
1.54

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Novel proline hydroxylase activities in the pneumocandin-producing fungus Glarea lozoyensis responsible for the formation of trans 3- and trans 4-hydroxyproline.

Appl. Microbiol. Biotechnol. 62(2-3) , 263-7, (2003)

Novel proline 3-hydroxylase (P3H) and proline 4-hydroxylase (P4H) activities that convert free l-proline to both trans 3- and trans 4-hydroxy- l-proline were detected in protein extracts of the anamor...

Insights on the evolution of prolyl 3-hydroxylation sites from comparative analysis of chicken and Xenopus fibrillar collagens.

PLoS ONE 6(5) , e19336, (2011)

Recessive mutations that prevent 3-hydroxyproline formation in type I collagen have been shown to cause forms of osteogenesis imperfecta. In mammals, all A-clade collagen chains with a GPP sequence at...

Conformational studies of peptides containing cis-3-hydroxy-D-proline.

J. Org. Chem. 69(21) , 7399-402, (2004)

Conformational analysis of peptides containing cis-3-hydroxy-d-proline (d-cis-3-Hyp) by NMR studies revealed that the 3-hydroxyl group in this amino acid plays a significant role in the overall three-...