4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

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Names

[ CAS No. ]:
43064-12-6

[ Name ]:
4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

[Synonym ]:
4-Phenyl-1,2,3,6-tetrahydropyridinehydrochloride
Pyridine, 1,2,3,6-tetrahydro-4-phenyl-, hydrochloride (1:1)
4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride (1:1)
4-phenyl-1,2,3,6-tetrahydropyridine,hydrochloride
4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride
1,2,3,6-Tetrahydro-4-phenylpyridine Hydrochloride
EINECS 256-071-5
MFCD00012752

Chemical & Physical Properties

[ Boiling Point ]:
267.9ºC at 760 mmHg

[ Melting Point ]:
200-204ºC

[ Molecular Formula ]:
C11H14ClN

[ Molecular Weight ]:
195.689

[ Flash Point ]:
119.9ºC

[ Exact Mass ]:
195.081482

[ PSA ]:
12.03000

[ LogP ]:
3.19410

[ Water Solubility ]:
Soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331-H351

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R23/24/25;R40

[ Safety Phrases ]:
S28-S36/37/39-S38-S45

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bromobenzene
  • N-Benzyl-4-piperidone
  • 1-BENZYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
  • 1-Benzyl-4-phenyl-4-piperidinol

DownStream

  • Roxindole
  • 5-[2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl]-1,3-oxazolidin-2-one
  • Fenpipalone
  • Ro 10-5824 dihydrochloride
  • 4-Phenylpiperidine
  • 4-Phenyl-1,2,3,6-tetrahydropyridinehydrochloride
  • 4-phenylpiperidinium chloride
  • 4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
  • 3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)propanoic acid
  • 4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butanimidamide

Articles

4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.

Bioorg. Med. Chem. Lett. 15(19) , 4221-5, (2005)

We have shown that a 4-phenyl-1,2,3,6-tetrahydropyridine fragment plays an important role in improving inhibitory potency against poly(ADP-ribose) polymerase-1 (PARP-1). Various benzamide analogues li...

Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models.

J. Ethnopharmacol. 134(2) , 414-21, (2011)

Polygalae radix, the root of Polygala tenuifolia Willd, has commonly been used for the treatment of amnesia and anxiety in traditional Korean medicine. The aim of this study was to investigate its neu...

Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

PLoS ONE 4(9) , e7247, (2009)

It has been shown that molecular hydrogen (H(2)) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegene...


More Articles

Related Compounds

  • 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
  • 3-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • 1-ethyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • 1-phenyl-4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-ium-1-yl)butan-1-one,chloride
  • 2,5-dimethyl-4-phenyl-1,2,3,6-tetrahydro-pyridine
  • Tert-butyl 5-fluoro-7-iodoindoline-1-carboxylate
  • Tert-butyl methyl2-methyl-2-(4-nitro-1h-pyrazol-1-yl)propylcarbamate
  • 2-(Aminomethyl)-4-(difluoromethyl)-3,5-diiodopyridine
  • {1-[amino(1-methyl-1H-pyrazol-4-yl)methyl]cyclobutyl}methanol
  • Tert-butyl 2-(4-amino-1h-pyrazol-1-yl)-2-methylpropylmethylcarbamate
  • 1-(Difluoromethyl)naphthalene-5-acetic acid
  • 4-bromo-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
  • 1-(2,2-Difluoroethyl)-3,4-dinitro-1H-pyrazole
  • Methyl 2-[3-(piperidin-4-ylmethyl)phenyl]acetate
  • 4-bromo-N-(4-ethylpyridin-2-yl)benzamide
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