10-(1-methylpiperidin-4-ylidene)-4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-4-ol

Names

[ CAS No. ]:
43076-12-6

[ Name ]:
10-(1-methylpiperidin-4-ylidene)-4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-4-ol

[Synonym ]:
9,10-Dihydro-4-(1-methyl-4-piperidyliden)-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-10-ol
10-hydroxy-ketotifen
4-(1-methyl-piperidin-4-ylidene)-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-ol

Chemical & Physical Properties

[ Density]:
1.242g/cm3

[ Boiling Point ]:
495.7ºC at 760 mmHg

[ Molecular Formula ]:
C19H21NOS

[ Molecular Weight ]:
311.44100

[ Flash Point ]:
253.6ºC

[ Exact Mass ]:
311.13400

[ PSA ]:
51.71000

[ LogP ]:
3.80300

[ Index of Refraction ]:
1.654

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • magnesium,1-methylpiperidin-4-ide,chloride
  • 10-bromo-4H-benzo[4,5]cyclohepta[1,2-b]thiophene-4-one
  • 4-(10-bromo-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methyl-piperidine
  • Ketotifen
  • 4H-Benzo[4,5]cyclohepta[1,2-b]thiophene-4-ol,10-methoxy-4-(1-methyl-4-piperidinyl)-
  • 10-Methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one

DownStream