Necrostatin-1

Suppliers

Names

[ CAS No. ]:
4311-88-0

[ Name ]:
Necrostatin-1

[Synonym ]:
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Necrostatin-1
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxoimidazolidin-4-one
Necrostatin 1
MTH-trp
4-Imidazolidinone, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-
5-indol-3-ylmethyl-3-methyl-2-thioxo-imidazolidin-4-one
Nec-1
Necroptotic Inhibitor,Nec-1
MTH-DL-Tryptophan
methyl-thiohydantoin-tryptophan

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
441.9±37.0 °C at 760 mmHg

[ Melting Point ]:
151ºC

[ Molecular Formula ]:
C13H13N3OS

[ Molecular Weight ]:
259.327

[ Flash Point ]:
221.1±26.5 °C

[ Exact Mass ]:
259.077942

[ PSA ]:
80.22000

[ LogP ]:
1.26

[ Appearance of Characters ]:
solid

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.738

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: >10 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
36/37/39

[ Safety Phrases ]:
36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl isothiocyanate
  • methyl tryptophan
  • DL-Tryptophan

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection.

Int. J. Med. Microbiol. 304(5-6) , 530-41, (2014)

Shigella infection in epithelial cells induces cell death which is accompanied by mitochondrial dysfunction. In this study the role of the mitochondrial fission protein, Drp1 during Shigella infection...

Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells.

Autophagy 10(7) , 1285-300, (2014)

Transition metal copper (Cu) can exist in oxidized or reduced states in cells, leading to cytotoxicity in cancer cells through oxidative stress. Recently, copper complexes are emerging as a new class ...

Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy.

Autophagy 11(2) , 214-24, (2015)

Both apoptosis ("self-killing") and autophagy ("self-eating") are evolutionarily conserved processes, and their crosstalk influences anticancer drug sensitivity and cell death. However, the underlying...


More Articles

Related Compounds

  • Necrostatin-1
  • Propane,1,1-bis(ethylsulfonyl)-2-methyl-
  • Pyridinium, 1- (2-hydroxy[1,1:3,1-terphenyl]-5-yl)-2,4, 6-triphenyl-, perchlorate (salt)
  • Cyclohexanecarboxylicacid, 1-methyl-3-oxo-, ethyl ester
  • 2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
  • 3-[1-(2,5-dimethylthiophen-3-yl)octadecyl]-4-propan-2-ylideneoxolane-2,5-dione