1-Methyl-1,4-diazepane

Names

[ Name ]:
1-Methyl-1,4-diazepane

[Synonym ]:
MFCD00059810
1-Methyl-1,4-diazepane
Hexahydro-1-methyl-1H-1,4-diazepine
1H-1,4-Diazepine, hexahydro-1-methyl-
N-Methylhomopiperazine
N-Methyl Homopiperazine
1-Methylhomopiperazine

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
157.4±8.0 °C at 760 mmHg

[ Melting Point ]:
33ºC

[ Molecular Formula ]:
C₆H₁₄N₂

[ Molecular Weight ]:
114.189

[ Flash Point ]:
54.3±9.4 °C

[ Exact Mass ]:
114.115700

[ PSA ]:
15.27000

[ LogP ]:
0.21

[ Vapour Pressure ]:
2.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.441

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R10;R22;R34

[ Safety Phrases ]:
S16-S26-S27-S36/37/39-S45

[ RIDADR ]:
UN 2920 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
4.1

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Methyl-1,4-diazepan-5-one
2-[(4-Aminobutyl)amino]ethanol
3-[(2-Hydroxyethyl)amino]propiononitrile
monomethylethanolaminopropionitrile

DownStream

4-(4-Methyl-1,4-diazepan-1-yl)aniline
1-methyl-4-(4-nitrophenyl)-1,4-diazepane
1H-1,4-Diazepine-1-carboxylicacid, hexahydro-4-methyl-, ethyl ester
2-(4-Methylperhydro-1,4-diazepin-1-yl)benzonitrile
Emedastine
4-(4-METHYL-1,4-DIAZEPAN-1-YL)BENZONITRILE 97
(E)-but-2-enedioic acid,2-(4-methyl-1,4-diazepan-1-yl)-1-(2-phenoxyethyl)benzimidazole
(E)-but-2-enedioic acid,2-(4-methyl-1,4-diazepan-1-yl)-1-(2-propoxyethyl)benzimidazole
1-(2-fluoro-4-nitrophenyl)-4-methyl-1,4-diazepane
1H-1,4-Diazepine,1-[(4-chlorophenyl)phenylmethyl]hexahydro-4-methyl-

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

Bioorg. Med. Chem. 23(9) , 2024-34, (2015)

Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[...

Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action.

Bioorg. Med. Chem. 8(2) , 373-80, (2000)

Novel benzimidazole derivatives were synthesized and their pharmacological activities were examined. These compounds showed a good suppressive action on histamine release from rat peritoneal mast cell...

Synthesis and characterization of a series of 4-methyl-1-[2-aryl-1-diazenyl]-1, 4-diazepanes and 1, 4-di-[2-aryl-1-diazenyl]-1, 4-diazepanes. Moser SL and Vaughan K.

Can. J. Chem. 82(!2) , 1725-35, (2004)

1-methyl-1,4-diazepane,hydrochloride
6,6-difluoro-1-methyl-1,4-diazepane dihydrochloride
1-methyl-4-(cyanomethyl)-1,4-diazepane
1-methyl-3-phenyl-1,4-diazepane
1-methyl-4-(aminoethyl)-1,4-diazepane hydrochloride
1-methyl-4-(4-nitrophenyl)-1,4-diazepane
5-oxo-N-(5-{[2-oxo-2-(pyrrolidin-1-yl)ethyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-1-phenylpyrrolidine-3-carboxamide
N-(4-acetamidophenyl)-2-((6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
N-[5-({[(2-methoxyethyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
2-methoxy-N-[5-[2-oxo-2-(oxolan-2-ylmethylamino)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
1-(4-fluorophenyl)-N-(5-((2-morpholinoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
1-(4-fluorophenyl)-5-oxo-N-(5-((pyridin-3-ylmethyl)thio)-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxamide
Ethyl 2-((5-(1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate
N-(5-((2-(1,3-dioxolan-2-yl)ethyl)thio)-1,3,4-thiadiazol-2-yl)-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
1-(2-methoxyphenyl)-5-oxo-N-[5-[2-oxo-2-(propan-2-ylamino)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide
N-{5,5-dioxo-2-phenyl-2H,4H,6H-5lambda6-thieno[3,4-c]pyrazol-3-yl}-2-(3-methoxyphenoxy)acetamide

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