(3β)-7-Dehydro Cholesterol

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Names

[ CAS No. ]:
434-16-2

[ Name ]:
(3β)-7-Dehydro Cholesterol

[Synonym ]:
delta7-Cholesterol
(3b)-7-Dehydrocholesterol
Cholesta-5,7-dien-3-ol, (3β)-
Cholesta-5,7-dien-3β-ol (8CI)
Cholesta-5,7-dien-3-β-ol
Provitamin D3
EINECS 207-100-5
Dehydrocholesterol
(3Beta)-7-Dehydro Cholesterol
(3b)-Cholesta-5,7-dien-3-ol
3β-Hydroxy-5,7-cholestadiene
Provitamine
cholesta-5,7-dien-3beta-ol
(-)-7-dehydrocholesterol
Dehydrocholesterin
(3β)-Cholesta-5,7-dien-3-ol
5,7-Cholestadien-3β-ol
7-DHC
7-Dehydrocholesterol
Provitamin D(sub 3)
MFCD00003624
Cholesta-5,7-dien-3β-ol
cholesta-5,7-dien-3b-ol
(3β)-7-Dehydrocholesterol

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
493.7±34.0 °C at 760 mmHg

[ Melting Point ]:
148-152 °C(lit.)

[ Molecular Formula ]:
C27H44O

[ Molecular Weight ]:
384.638

[ Flash Point ]:
212.3±17.9 °C

[ Exact Mass ]:
384.339203

[ PSA ]:
20.23000

[ LogP ]:
9.46

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.536

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FZ5650000
CHEMICAL NAME :
Cholesta-5,7-dien-3-beta-ol
CAS REGISTRY NUMBER :
434-16-2
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C27-H44-O
MOLECULAR WEIGHT :
384.71
WISWESSER LINE NOTATION :
L E5 B666 JU LUTJ A1 E1 FY1&3Y1&1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 gm/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 60,525,1973

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
FZ5650000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • cholesta-1,5,7-trien-3β-ol
  • cholesterol
  • Cholest-5-ene-3β,7β-diol dibenzoate
  • 7-Oxo Cholesterol 3-Acetate
  • (-)-Cholesteryl acetate
  • 1,4-Benzoquinone
  • cholesta-1,4,6-trien-3-one
  • 3-acetoxy-1,3,5,7-cholestatetraene
  • 3-acetoxy-cholesta-3,5,7-triene

DownStream

  • Vitamin D3
  • Previtamin D3
  • Tachysterol 3
  • Lumisterol 3
  • tachysterol
  • 10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • Lathosterol
  • Δ8(14)-Cholestenol
  • Androstenedione

Articles

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

PLoS ONE 4(4) , e5182, (2009)

Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium up...

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

J. Chromatogr. A. 1364 , 214-22, (2014)

We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of...

The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production.

J. Bacteriol. 197 , 3698-707, (2015)

Mycobacterium leprae induces the formation of lipid droplets, which are recruited to pathogen-containing phagosomes in infected macrophages and Schwann cells. Cholesterol is among the lipids with incr...


More Articles

Related Compounds

  • (3β)-7-dehydro-1α,25-diacetoxycholesterol
  • (3β)-7,17-Dioxoandrost-5-en-3-yl acetate
  • 6,7-Dehydro Triamcinolone Acetonide
  • 6,7-Dehydro Norethindrone Acetate
  • 6,7-dehydro-3-tropoyloxytropane
  • [(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
  • 1-[3-(1-methyl-1H-pyrazol-4-yl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]prop-2-en-1-one
  • 1-[4-(3-Methyl-1-benzothiophene-2-carbonyl)piperazin-1-yl]prop-2-en-1-one
  • N-[4-(azepan-1-yl)-2-methylbutan-2-yl]prop-2-enamide
  • N-({7-hydroxy-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}methyl)prop-2-enamide
  • 1-[2-(2-Methyl-1,3-thiazol-4-yl)pyrrolidin-1-yl]prop-2-en-1-one
  • N-(1-cyanocyclopentyl)-4-[(2-hydroxyethyl)sulfamoyl]benzamide
  • N-(cyanomethyl)-1-(trifluoromethyl)cyclopentane-1-carboxamide
  • N-[(1R)-1-cyano-2-methylpropyl]-2,2-difluoro-1-methylcyclopropane-1-carboxamide
  • N-[(3-chloropyrazin-2-yl)methyl]-9-ethyl-9H-purin-6-amine
  • N-[(3-chloropyrazin-2-yl)methyl]-2-ethyl-6-methylpyrimidin-4-amine
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