Ajmalicine hydrochloride

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Names

[ CAS No. ]:
4373-34-6

[ Name ]:
Ajmalicine hydrochloride

[Synonym ]:
Circolene
Pytetrahydroserpentine
Einecs 224-471-9
d-Yohimbine
δ-Yohimbine
RAUBASINE HYDROCHLORIDE
AJMALICINE HCL
(19α)-16,17-Didehydro-19-methyl-oxayohimban-16-carboxylic acid methyl ester
Methyl (19α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate
Methyl (4S,4aR,13bS,14aS)-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate
Raubasine
Ajmalicine
ajmalicine,monohydrochloride
Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19α)-
Lamuran
Methyl-(4S,4aR,13bS,14aS)-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]chinolizin-1-carboxylat
Methyl-(19α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylat
AJMALICIN HCL
Tetrahydroserpentine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
524.0±50.0 °C at 760 mmHg

[ Melting Point ]:
275-300ºC

[ Molecular Formula ]:
C21H24N2O3

[ Molecular Weight ]:
352.427

[ Flash Point ]:
270.7±30.1 °C

[ Exact Mass ]:
352.178680

[ PSA ]:
54.56000

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.656

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AX7890000
CHEMICAL NAME :
Ajmalicine, hydrochloride
CAS REGISTRY NUMBER :
4373-34-6
LAST UPDATED :
199306
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H24-N2-O3.Cl-H
MOLECULAR WEIGHT :
388.93
WISWESSER LINE NOTATION :
T F6 D5 C666 EM ON SO TU&&TTTJ R1 UVO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932 Volume(issue)/page/year: -,-,1932
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00444

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3

[ RTECS ]:
AX7890000

Related Compounds

  • Ajmalicine
  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • Elacridar hydrochloride
  • dodecylamine hydrochloride
  • 5-{[(4-Bromo-3-methylphenyl)sulfonyl]methyl}furan-2-carboxylic acid
  • 5-({[4-(2-Methylpropyl)phenyl]sulfonyl}methyl)furan-2-carboxylic acid
  • 5-{[(2,4,5-Trimethylphenyl)sulfonyl]methyl}furan-2-carboxylic acid
  • 5-{[(5-Chloro-2-methoxyphenyl)sulfonyl]methyl}furan-2-carboxylic acid
  • 5-{[(5-Chlorothiophen-2-yl)sulfonyl]methyl}furan-2-carboxylic acid
  • Methyl 2-[(3-chlorobenzyl)(methylsulfonyl)amino]benzoate
  • 4-{[3-(Pyrrolidin-1-yl)pyrazin-2-yl]oxy}benzoic acid
  • 2-Chloro-4-[4-(3-methoxyphenyl)piperazin-1-yl]pyrimidine
  • Methyl 4-(3-chloropyrazin-2-yloxy)benzoate
  • 1-(6-chloropyrimidin-4-yl)-N-(propan-2-yl)piperidine-4-carboxamide
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