Epipodophyllotoxin

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Names

[ CAS No. ]:
4375-07-9

[ Name ]:
Epipodophyllotoxin

[Synonym ]:
Sunphenon EGC
Epipodophyllotoxin
EPIGALLOCATECHIN
Teacatechin II
epi
Galloepicatechin
epigallocatechol
Greenteacatechins

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Boiling Point ]:
597.9ºC at 760 mmHg

[ Melting Point ]:
160.3 °C

[ Molecular Formula ]:
C22H22O8

[ Molecular Weight ]:
414.40500

[ Flash Point ]:
210.2ºC

[ Exact Mass ]:
414.13100

[ PSA ]:
92.68000

[ LogP ]:
2.40920

[ Index of Refraction ]:
1.605

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV2520000
CAS REGISTRY NUMBER :
4375-07-9
BEILSTEIN REFERENCE NO. :
0099162
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C22-H22-O8
MOLECULAR WEIGHT :
414.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
135 mg/kg
SEX/DURATION :
female 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
20 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,512,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5374 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 214 (estimated) No. of Female Employees: 214 (estimated)

Precursor & DownStream

Precursor

DownStream

  • Picropodophyllotoxin
  • Podophyllotoxin
  • (3aR,4S,9R,9aR)-4,6,7-trihydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one
  • Acetylepipodophyllotoxin

Related Compounds

  • Epipodophyllotoxin-β-D-glucopyranosid
  • O-ethyl-epipodophyllotoxin
  • 4-bromo-4'-demethyl-epipodophyllotoxin
  • O-ethyl-epipodophyllotoxin
  • 4'-benzyloxycarbonyl-epipodophyllotoxin
  • 4'-demethyl-epipodophyllotoxin
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-Hydroxy-4-(1-piperidinylmethyl)-2-naphthalenecarboxaldehyde
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • (Oxolan-2-yl)methyl 2-methylbutanoate
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine