Afatinib (BIBW2992)

Suppliers

Names

[ CAS No. ]:
439081-18-2

[ Name ]:
Afatinib (BIBW2992)

[Synonym ]:
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
(2E)-N-(4-[(3-chloro-4-fluorophenyl)amino]-7-{[(3S)-tetrahydrofuran-3-yl]oxy}quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Afatinib
Tovok
Tomtovok
BIBW2992
(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydro-3-furanyloxy]-6-quinazolinyl}-4-(dimethylamino)-2-butenamide
Gilotrif
BIBW 2992

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
676.9±55.0 °C at 760 mmHg

[ Melting Point ]:
100 - 102 °C

[ Molecular Formula ]:
C24H25ClFN5O3

[ Molecular Weight ]:
485.94

[ Flash Point ]:
363.2±31.5 °C

[ Exact Mass ]:
485.162994

[ PSA ]:
88.61000

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.668

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • (S,E)-4-broMo-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enaMide
  • afatinib
  • Afatinib Impurity 74
  • (2Z)-Afatinib
  • Afatinib oxalate
  • 2-[4-Cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid
  • 2-Amino-2-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol
  • (S)-2-Amino-5-o-tolylpentanoic acid
  • I(2)-Alanine, N-[(2,3-dihydro-5,6-dimethyl-3-oxo-4-pyridazinyl)carbonyl]-N-methyl-, methyl ester
  • Tert-butyl 1-isopropyl-3,3-dimethoxycyclopentanecarboxylate
  • N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • N-Cyclopropyl-2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzenemethanamine
  • 4-(Propan-2-yl)phenyl sulfamate
  • N-{2-[(4-chlorophenyl)sulfanyl]ethyl}tetrahydro-2H-pyran-4-carboxamide
  • tert-butyl 9-hydroxy-2,3-dihydrobenzo[f][1,4]oxazepine-4(5H)-carboxylate
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