2-(2,6-dimethylanilino)pyridine-3-carboxylic acid

Names

[ CAS No. ]:
4394-04-1

[ Name ]:
2-(2,6-dimethylanilino)pyridine-3-carboxylic acid

[Synonym ]:
Metanixin
2-(2',6'-Dimethylphenylamin)-3-pyridincarboxylsaeure
2-[(2,6-dimethylphenyl)amino]pyridine-3-carboxylic acid
Acido nixilico
2-(2,6-xylidino)-nicotinic acid
Acidum nixylicum
Metanixine [INN-French]
Metanixino [Spanish]
2-(2,6-dimethyl-anilino)-nicotinic acid
2-(2,6-Dimethyl-anilino)-nicotinsaeure
Metanixinum [Latin]
Metanixinum [INN-Latin]
Metanixino [INN-Spanish]
Metanixine [French]
Acide nixylique

Chemical & Physical Properties

[ Density]:
1.25 g/cm3

[ Boiling Point ]:
393.972ºC at 760mmHg

[ Molecular Formula ]:
C14H14N2O2

[ Molecular Weight ]:
242.27300

[ Flash Point ]:
192.068ºC

[ Exact Mass ]:
242.10600

[ PSA ]:
62.22000

[ LogP ]:
3.21320

[ Index of Refraction ]:
1.646

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT2999350
CHEMICAL NAME :
Nicotinic acid, 2-(2,3-xylidino)-
CAS REGISTRY NUMBER :
4394-04-1
BEILSTEIN REFERENCE NO. :
0482454
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C14-H14-N2-O2
MOLECULAR WEIGHT :
242.30
WISWESSER LINE NOTATION :
T6NJ BMR B1 C1& CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
645 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
385 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Chloronicotinic acid
  • 2,6-xylidine

DownStream

  • 3-butyl-1-(2,6-dimethylphenyl)-4-hydroxy-1,8-naphthyridin-2-one

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-(2,6-difluorophenyl)pyridine-3-carboxylic acid
  • 2-(2,4-dimethylanilino)pyridine-3-carboxylic acid
  • 2-(2,5-dimethylanilino)pyridine-3-carboxylic acid
  • 2-(2,6-dichloro-3-methoxyanilino)pyridine-3-carboxylic acid
  • Nixylic acid
  • 2-(2,4-dichlorophenyl)pyridine-3-carboxylic acid
  • 7-hydroxy-3-(4-hydroxyphenyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
  • 1-(4-(6-Nitrobenzo[d]thiazol-2-yl)piperazin-1-yl)-2-(phenylsulfonyl)ethanone
  • 2-((4-Fluorophenyl)thio)-1-(4-(6-nitrobenzo[d]thiazol-2-yl)piperazin-1-yl)ethanone
  • 2,3-Dihydro-2-oxo-1-(phenylmethyl)-1H-indole-3-acetonitrile
  • (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(4-(4-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
  • 1-(2-cyanoethyl)-3-(1-ethyl-1H-indol-3-yl)-1-methylurea
  • (2-Chloro-5-nitrophenyl)(4-(4-ethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
  • (E)-1-(4-(4-methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)-3-(3-nitrophenyl)prop-2-en-1-one
  • (5-Bromothiophen-2-yl)(4-(4-methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
  • (Z)-1-(4-(4-methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)-3-(4-nitrophenyl)prop-2-en-1-one
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