2-(2,6-dimethylanilino)pyridine-3-carboxylic acid

Names

[ Name ]:
2-(2,6-dimethylanilino)pyridine-3-carboxylic acid

[Synonym ]:
Metanixin
2-(2',6'-Dimethylphenylamin)-3-pyridincarboxylsaeure
2-[(2,6-dimethylphenyl)amino]pyridine-3-carboxylic acid
Acido nixilico
2-(2,6-xylidino)-nicotinic acid
Acidum nixylicum
Metanixine [INN-French]
Metanixino [Spanish]
2-(2,6-dimethyl-anilino)-nicotinic acid
2-(2,6-Dimethyl-anilino)-nicotinsaeure
Metanixinum [Latin]
Metanixinum [INN-Latin]
Metanixino [INN-Spanish]
Metanixine [French]
Acide nixylique

Chemical & Physical Properties

[ Density]:
1.25 g/cm3

[ Boiling Point ]:
393.972ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₄N₂O₂

[ Molecular Weight ]:
242.27300

[ Flash Point ]:
192.068ºC

[ Exact Mass ]:
242.10600

[ PSA ]:
62.22000

[ LogP ]:
3.21320

[ Index of Refraction ]:
1.646

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2999350

CHEMICAL NAME :: Nicotinic acid, 2-(2,3-xylidino)-

CAS REGISTRY NUMBER :: 4394-04-1

BEILSTEIN REFERENCE NO. :: 0482454

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H14-N2-O2

MOLECULAR WEIGHT :: 242.30

WISWESSER LINE NOTATION :: T6NJ BMR B1 C1& CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 645 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 385 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,157,1967

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Chloronicotinic acid
2,6-xylidine

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

2-(2,6-difluorophenyl)pyridine-3-carboxylic acid
2-(2,4-dimethylanilino)pyridine-3-carboxylic acid
2-(2,5-dimethylanilino)pyridine-3-carboxylic acid
2-(2,6-dichloro-3-methoxyanilino)pyridine-3-carboxylic acid
Nixylic acid
2-(2,4-dichlorophenyl)pyridine-3-carboxylic acid
2-[3-(cyclopentylmethyl)-4H-1,2,4-triazol-4-yl]-4-methylpentanoic acid
3-[3-(4,4-difluorocyclohexyl)-5-methyl-4H-1,2,4-triazol-4-yl]propanoic acid
3-(2-cyclopentylethyl)-4-(pyrrolidin-3-yl)-4H-1,2,4-triazole
(2R)-4-[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]butan-2-amine
(E)-4-(2-Chlorothiazol-5-yl)but-3-en-2-one
3-Methoxy-5-[(4-methoxypiperidin-4-yl)methyl]pyridine
4-(3-Aminobut-1-en-1-yl)benzene-1,2,3-triol
tert-butyl N-[4-fluoro-2-(2-isocyanatoethyl)phenyl]carbamate
O-{[1-(2-methylfuran-3-yl)cyclopropyl]methyl}hydroxylamine
[4,4-Difluoro-1-(4-methoxy-3,5-dimethylphenyl)cyclohexyl]methanamine

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