2,5-bis(bis-(2-chloroethyl)aminomethyl) hydroquinone

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Names

[ Name ]:
2,5-bis(bis-(2-chloroethyl)aminomethyl) hydroquinone

[Synonym ]:
2,5-Bis-{[bis-(2-chlor-aethyl)-amino]-methyl}-hydrochinon
Hydroquinone mustard
2,5-bis-{[bis-(2-chloro-ethyl)-amino]-methyl}-hydroquinone
Weatherbee mustard

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₅Cl₅N₂O₂

[ Molecular Weight ]:
454.64700

[ Exact Mass ]:
452.03600

[ PSA ]:
46.94000

[ LogP ]:
4.45900

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX4200000

CHEMICAL NAME :: Hydroquinone, 2,5-bis((bis(2-chloroethyl)amino)methyl)-

CAS REGISTRY NUMBER :: 4420-79-5

BEILSTEIN REFERENCE NO. :: 2888141

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H24-Cl4-N2-O2

MOLECULAR WEIGHT :: 418.22

WISWESSER LINE NOTATION :: G2N2G1R BQ EQ D1N2G2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 17,63,1962

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 17,56,1962

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - leukopenia Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1800 ug/kg

TOXIC EFFECTS :: Blood - leukopenia Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg/4W

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 36,915,1966

Safety Information

[ HS Code ]:
2922299090

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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