5-Fluoroisatin

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Names

[ CAS No. ]:
443-69-6

[ Name ]:
5-Fluoroisatin

[Synonym ]:
5-Fluoroisatin
5-Fluoro-2,3-indolinedione
5-fluoroindoline-2,3-dione
1H-Indole-2,3-dione, 5-fluoro-
5-Fluoroindole-2,3-dione
5-Fluoro-1H-indole-2,3-dione
5-Fluoro-2,3-indoledione
MFCD00022795

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
417.9ºC at 760mmHg

[ Melting Point ]:
224-227 °C(lit.)

[ Molecular Formula ]:
C8H4FNO2

[ Molecular Weight ]:
165.12

[ Flash Point ]:
206.5ºC

[ Exact Mass ]:
165.022614

[ PSA ]:
46.17000

[ LogP ]:
0.61

[ Index of Refraction ]:
1.584

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (E)-N-(4-fluorophenyl)-2-(hydroxyimino)acetamide
  • Ethanol,2,2,2-trichloro-1-ethoxy-
  • 4-Fluoroaniline
  • 4-fluoroisonitrosoacetanilide
  • 5-Iodo-1H-indole-2,3-dione
  • Oxalyl chloride
  • Chloral hydrate
  • 3,3-dibromo-5-fluoroindolin-2-one
  • 2-Bromo-4-fluoroaniline

DownStream

  • 5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4 -dimethyl-1H-pyrrole-3-carboxylic acid
  • 5-Fluoroisatonic anhydride
  • Sunitinib malate
  • 5-fluoro-3'-p-tolyl-1'H-spiro[indoline-3,2'-quinazoline]-2,4'(3'H)-dione
  • 2-Amino-N-(4-methylphenyl)benzamide
  • sunitinib
  • 2-Amino-5-fluorobenzoic acid
  • 5-Fluoro-1H-indazole-3-carbaldehyde
  • 4-QUINOLINECARBOXYLIC ACID, 6-FLUORO-
  • Methyl 5-fluoro-1H-indazole-3-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Counter-Current chromatography separation of isatin derivatives using the sandmeyer methodology. Almeida MR, et al.

J. Braz. Chem. Soc. 21(4) , 764-9, (2010)

A Novel Preparation of a-Substituted Tryptamines from Isatins. Franklin CS and White AC.

J. Chem. Soc. 2 , 1335-37, (1963)

¹⁹F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction.

Chem. Commun. (Camb.) 50(82) , 12311-4, (2014)

We report a newly discovered oxidative decarbonylation reaction of isatins that is selectively mediated by peroxynitrite (ONOO(-)) to provide anthranilic acid derivatives. We have harnessed this rapid...


More Articles

Related Compounds

  • 6-Bromo-5-fluoroisatin
  • 4-chloro-5-fluoroisatin
  • 4-methyl-5-fluoroisatin
  • 6-methyl-5-fluoroisatin
  • 4-chloro-5-fluoroisatin
  • 1-(4-Fluorophenyl)-5-fluoroisatin
  • 4-(1H-1,3-benzodiazol-2-yl)-1,1-difluorobutan-2-one
  • 5-(3-Amino-1,1,1-trifluoropropan-2-yl)thiophene-3-carbonitrile
  • 3-Methyl-1-(2-nitrobenzenesulfonyl)azetidin-3-amine
  • tert-butyl N-[3-(4-fluorophenyl)-2-methyl-1-oxobutan-2-yl]carbamate
  • 3-(3-Fluoro-4-nitrophenyl)-3-hydroxypropanenitrile
  • 2,2-Difluoro-1-[4-(methoxymethyl)phenyl]cyclopropan-1-amine
  • 2-fluoro-1-(4,5,6,7-tetrahydro-1H-indol-2-yl)ethan-1-ol
  • 2-(1-Amino-2-methylpropan-2-yl)-5-methoxyphenol
  • 5-[(3S)-3-aminobutyl]-4-bromo-2-methoxyphenol
  • 4-{1-[(Ethylamino)methyl]cyclobutyl}butan-1-amine
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