5-Fluoroisatin

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Names

[ CAS No. ]:
443-69-6

[ Name ]:
5-Fluoroisatin

[Synonym ]:
5-Fluoroisatin
5-Fluoro-2,3-indolinedione
5-fluoroindoline-2,3-dione
1H-Indole-2,3-dione, 5-fluoro-
5-Fluoroindole-2,3-dione
5-Fluoro-1H-indole-2,3-dione
5-Fluoro-2,3-indoledione
MFCD00022795

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
417.9ºC at 760mmHg

[ Melting Point ]:
224-227 °C(lit.)

[ Molecular Formula ]:
C8H4FNO2

[ Molecular Weight ]:
165.12

[ Flash Point ]:
206.5ºC

[ Exact Mass ]:
165.022614

[ PSA ]:
46.17000

[ LogP ]:
0.61

[ Index of Refraction ]:
1.584

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (E)-N-(4-fluorophenyl)-2-(hydroxyimino)acetamide
  • Ethanol,2,2,2-trichloro-1-ethoxy-
  • 4-Fluoroaniline
  • 4-fluoroisonitrosoacetanilide
  • 5-Iodo-1H-indole-2,3-dione
  • Oxalyl chloride
  • Chloral hydrate
  • 3,3-dibromo-5-fluoroindolin-2-one
  • 2-Bromo-4-fluoroaniline

DownStream

  • 5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4 -dimethyl-1H-pyrrole-3-carboxylic acid
  • 5-Fluoroisatonic anhydride
  • Sunitinib malate
  • 5-fluoro-3'-p-tolyl-1'H-spiro[indoline-3,2'-quinazoline]-2,4'(3'H)-dione
  • 2-Amino-N-(4-methylphenyl)benzamide
  • sunitinib
  • 2-Amino-5-fluorobenzoic acid
  • 5-Fluoro-1H-indazole-3-carbaldehyde
  • 4-QUINOLINECARBOXYLIC ACID, 6-FLUORO-
  • Methyl 5-fluoro-1H-indazole-3-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Counter-Current chromatography separation of isatin derivatives using the sandmeyer methodology. Almeida MR, et al.

J. Braz. Chem. Soc. 21(4) , 764-9, (2010)

A Novel Preparation of a-Substituted Tryptamines from Isatins. Franklin CS and White AC.

J. Chem. Soc. 2 , 1335-37, (1963)

¹⁹F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction.

Chem. Commun. (Camb.) 50(82) , 12311-4, (2014)

We report a newly discovered oxidative decarbonylation reaction of isatins that is selectively mediated by peroxynitrite (ONOO(-)) to provide anthranilic acid derivatives. We have harnessed this rapid...


More Articles

Related Compounds

  • 6-Bromo-5-fluoroisatin
  • 4-chloro-5-fluoroisatin
  • 4-methyl-5-fluoroisatin
  • 6-methyl-5-fluoroisatin
  • 4-chloro-5-fluoroisatin
  • 1-(4-Fluorophenyl)-5-fluoroisatin
  • L-Cysteine, N-[(5-methyl-4-isoxazolyl)carbonyl]-
  • (2S)-2-({3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]oxan-3-yl}formamido)butanoic acid
  • 2-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-2-(1-methyl-1H-pyrazol-4-yl)acetic acid
  • 2-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-octahydrocyclopenta[c]pyrrole-1-carboxylic acid
  • 2-{4-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-1H-pyrazol-1-yl}acetic acid
  • (1RS,2SR)-2-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]cyclopentane-1-carboxylic acid
  • 5-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-difluoropropanamido]methyl}-1,2-oxazole-3-carboxylic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhex-4-enamido]-3-hydroxy-2-methylpropanoic acid
  • (2S)-3-(dimethylamino)-2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]pentanamido}propanoic acid
  • rac-(1R,3R,5R)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-enamido]bicyclo[3.1.0]hexane-1-carboxylic acid
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