Vandetanib(ZD6474)

Suppliers

Names

[ CAS No. ]:
443913-73-3

[ Name ]:
Vandetanib(ZD6474)

[Synonym ]:
Vandetanib
4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
ZACTIMA
ZD 6474
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
Caprelsa
ZD6474
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Vandetanib for research

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
538.2±50.0 °C at 760 mmHg

[ Melting Point ]:
240-243ºC

[ Molecular Formula ]:
C22H24BrFN4O2

[ Molecular Weight ]:
475.354

[ Flash Point ]:
279.3±30.1 °C

[ Exact Mass ]:
474.106659

[ PSA ]:
59.51000

[ LogP ]:
5.51

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.629

[ Storage condition ]:
-20?C Freezer

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • N-DeMethyl Vandetanib
  • TERT-BUTYL 4-(((4-((4-BROMO-2-FLUOROPHENYL)AMINO)-6-METHOXYQUINAZOLIN-7-YL)OXY)METHYL)PIPERIDINE-1-CARBOXYLATE
  • 4-Bromo-2-fluoroaniline
  • 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline
  • 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
  • 4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol
  • 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • VANDETANIB
  • Vandetanib trifluoroacetate
  • Vandetanib-d6
  • Vandetanib-d4
  • Vandetanib hydrochloride
  • Hydroxy Vandetanib-d4
  • Methyl 3-(ethylsulfanyl)-2-hydroxypropanoate
  • (4R,5S)-4-(Fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-oxazole
  • (2R)-2-(3,5-dichlorophenyl)oxirane
  • (2S)-2-(3,5-dichlorophenyl)oxirane
  • (3R)-3-(2-methylpropyl)-1,4-diazepan-2-one
  • (3S)-3-(2-methylpropyl)-1,4-diazepan-2-one
  • 5-(4-{6-Tert-butyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}piperidine-1-carbonyl)-2-(trifluoromethyl)pyridine
  • (2R,6S)-2,6-Dimethyl-4-(piperidin-4-ylmethyl)morpholine;hydrochloride
  • (2S)-3-sulfanyl-2-(2,2,2-trifluoroacetamido)propanoic acid
  • 1-[6-(1H-pyrazol-1-yl)pyridin-2-yl]ethan-1-one
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