1-(2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine

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Names

[ CAS No. ]:
4442-59-5

[ Name ]:
1-(2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine

[Synonym ]:
1,4-BENZODIOXAN-2-METHYLAMINE
C-(2,3-dihydrobenzo[1,4]dioxin-2-yl)methylamine
2-aminomethylbenzodioxane
1-(2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine
1,4-Benzodioxin-2-methanamine, 2,3-dihydro-
2,3-Dihydro-1,4-benzodioxin-2-ylmethylamine
Fourneau 946
2-aminomethyl-1,4-benzodioxan
1-(2,3-dihydro-1,4-benzodioxin-2-yl)methylamine
(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)amine
2,3-dihydro-1,4-benzodioxin-2-methanamine
MFCD00203985
2-(3-CHLORO-4-FLUOROPHENOXY)ACETOHYDRAZIDE
2-aminomethyl-2,3-dihydro-1,4-benzodioxine
LP 1
2-aminomethylbenzodioxan
Aminomethylbenzodioxan
EINECS 224-671-6
LP 1 (pharmaceutical)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
266.0±19.0 °C at 760 mmHg

[ Melting Point ]:
184-188°C

[ Molecular Formula ]:
C9H11NO2

[ Molecular Weight ]:
165.189

[ Flash Point ]:
124.1±28.8 °C

[ Exact Mass ]:
165.078979

[ PSA ]:
44.48000

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.545

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF3676000
CHEMICAL NAME :
1,4-Benzodioxan-2-methylamine
CAS REGISTRY NUMBER :
4442-59-5
BEILSTEIN REFERENCE NO. :
0150152
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H11-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 55,15,1937

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
UN 2735

[ RTECS ]:
DF3676000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,3-DIHYDROBENZO[B][1,4]DIOXINE-2-CARBONITRILE
  • 2,3-Dihydro-1,4-benzodioxin-2-ylmethanol
  • 2-azidomethyl-2,3-dihydro-1,4-benzodioxine
  • 1,4-Benzodioxin-2-methanol, 2,3-dihydro-, 4-methylbenzenesulfonate
  • 1,4-Benzodioxin,2-(chloromethyl)-2,3-dihydro-

DownStream

  • (R)-2,3-Dihydro-1,4-benzodioxin-2-methanamine
  • 1-(2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine
  • 1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL-
  • 3-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-1-pyrrolidin-1-ylpropan-1-one
  • 2-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-1-piperidin-1-ylethanone
  • 3-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-1-piperidin-1-ylpropan-1-one
  • 3-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-1-morpholin-4-ylpropan-1-one
  • 4-[N-(1,4-Benzodioxan-2-ylmethyl)glycyl]morpholine
  • Guanoxan
  • 2-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)ethanol

Related Compounds

  • 1-(2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine
  • N-Benzyl-1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine
  • (1-((2,3-Dihydro-1,4-benzodioxin-2-yl)methyl)-4-piperidinyl)(4-hydroxy phenyl)methanone
  • 1-(2,3-Dihydro-1,4-benzodioxin-2-yl)ethanone
  • 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)ETHAN-1-ONE
  • 1-(7-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHANAMINE
  • Methanone,(2,3-dihydro-1h-indol-5-yl)[4-(2-propyn-1-yl)-1-piperazinyl]-
  • 3-(4-Amino-3-nitrophenyl)-2-benzyl-3-hydroxyisoindolin-1-one
  • 1-Ethyl-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
  • 1h-Indole-5-carboxamide,n-[2-(ethylamino)-2-oxoethyl]-2,3-dihydro-n-methyl-
  • 4-Iodo-3-methyl-1-[(4-methylphenyl)sulfonyl]-1h-pyrazole
  • 1h-Indole-5-carboxamide,2,3-dihydro-n-methyl-n-[1-(5-methyl-2-thienyl)ethyl]-
  • [4-(8-Bromo-imidazo[4,5-c]quinolin-1-yl)-phenyl]-acetonitrile
  • 1-(2-Methoxy-4-methylphenyl)cyclopropanecarboxylic acid
  • 2-[(3-Oxo-3,4-dihydro-2h-1,4-benzoxazine-6-yl)carbonyl]-n-(2-phenylethyl)benzamide
  • (3-Aminophenyl)(3,4-dihydro-7-hydroxy-2(1H)-isoquinolinyl)methanone
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