2,4,5-Trifluorobenzoic acid

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Names

[ CAS No. ]:
446-17-3

[ Name ]:
2,4,5-Trifluorobenzoic acid

[Synonym ]:
2,4,5-Trifluorobenzoic acid
2,4,5-trifluorobenzoicacid
MFCD00013306
2,4,5-Trifluor-benzoesaeure
Benzoic acid, 2,4,5-trifluoro-
2,4,5-trifluorobenzenecarboxylic acid
QVR BF DF EF
2,4,5-trifluorobenzoate

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
241.9±35.0 °C at 760 mmHg

[ Melting Point ]:
94-96 °C(lit.)

[ Molecular Formula ]:
C₇H₃F₃O₂

[ Molecular Weight ]:
176.093

[ Flash Point ]:
100.1±25.9 °C

[ Exact Mass ]:
176.008514

[ PSA ]:
37.30000

[ LogP ]:
2.32

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.491

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3,4,6-trifluorophthalic acid
2',4',5'-Trifluoroacetophenone
1-Bromo-2,4,5-trifluorobenzene
2,4,5-Trifluoro-3-bromobenzoic acid
1,2,4-Trifluorobenzene
Tetrachlorophthalic anhydride
1,2,3,5-Tetrafluorobenzene
3,4,6-trichlorophthalic acid
4,5,7-trichloro-2-methylisoindole-1,3-dione
N-Methyltetrachlorophthalimide

DownStream

1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
1,2,4-Trifluorobenzene
Methyl 2,4,5-trifluorobenzoate
tert-butyl 2,4,5-trifluorobenzoate
2,4,5-Trifluorobenzoyl chloride
Ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate
Sarafloxacin
2,4,5-Trifluorobenzamide
Benzoyl fluoride, 3-chloro-2,4,5-trifluoro- (9CI)
3-Chloro-2,4,5-trifluorobenzoic acid

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist.

Chem. Pharm. Bull. 50(7) , 941-59, (2002)

In search of a dopamine D2 and serotonin 5-HT3 receptors dual antagonist as a potential broad antiemetic agent, a number of benzamides were prepared from 4-amino-5-chloro-2-methoxybenzoic acid derivat...

An Expedient Route to the Quinolone Antibacterial Intermediate, 2, 4, 5-Trifluorobenzoic Acid. O'Reilly NJ, et al.

Synlett 1990(10) , 609-610, (1990)

3-AMINO-2,4,5-TRIFLUOROBENZOIC ACID
3-ethyl-2,4,5-trifluorobenzoic acid
3-bromo-2,4,5-trifluorobenzoic acid
3-Bromo-2,4,5-trifluorobenzoic acid
2,4,5-trifluorobenzoic acid chloride
3-Ethoxy-2,4,5-trifluorobenzoic acid
(2S)-4-(pyridin-4-yl)butan-2-amine
2-[1-(Cyclopropylmethyl)piperidin-4-yl]acetic acid
4-cyclopropyl-5-(piperidin-4-yl)-4H-1,2,4-triazole-3-thiol
8-bromo-7-(3-chlorobenzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
4-Ethyl-2-(trifluoromethyl)aniline
5-methyl-2-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1H-imidazole
Methyl2-methyl-3-sulfopropanoate
3-(3-Fluorophenyl)-5-(pyrrolidin-2-yl)-1,2,4-oxadiazole hydrochloride
2-[4-(2-Nitroanilino)phenyl]ethanol
2-(Chloromethyl)-4-phenyl-1,3-thiazole hydrochloride

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