N-2,5-DIIODOBENZOYL-N′,N′,N″,N″-DIETHYL-ENEPHOSPHORTRIAMIDE

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Names

[ CAS No. ]:
4460-32-6

[ Name ]:
N-2,5-DIIODOBENZOYL-N′,N′,N″,N″-DIETHYL-ENEPHOSPHORTRIAMIDE

[Synonym ]:
Diiodbenzoteph
Dijodbenzotef
Diiodobenzoteph
Diiodobenzotef
Diiodobenzotepa
2,5-Diodobenzo-TEPA

Chemical & Physical Properties

[ Density]:
2.31g/cm3

[ Molecular Formula ]:
C₁₁H₁₂I₂N₃O₂P

[ Molecular Weight ]:
503.01500

[ Exact Mass ]:
502.87600

[ PSA ]:
62.00000

[ LogP ]:
2.63160

[ Index of Refraction ]:
1.765

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV2352000

CHEMICAL NAME :: Benzamide, N-(bis(1-aziridinyl)phosphinyl)-2,5-diiodo-

CAS REGISTRY NUMBER :: 4460-32-6

BEILSTEIN REFERENCE NO. :: 1324621

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-I2-N3-O2-P

MOLECULAR WEIGHT :: 503.03

WISWESSER LINE NOTATION :: T3NTJ APO&MVR BI EI&- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 12,689,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 41,135,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 7,91,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 16,626,1982

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

2-(1-methyl-1H-pyrazol-4-yl)-2-(2,2,2-trifluoro-N-methylacetamido)acetic acid
1-{2-Azadispiro[3.1.3^{6}.1^{4}]decan-2-yl}ethan-1-one
2-Methanesulfonyl-2-azadispiro[3.1.3^{6}.1^{4}]decane
(3-Bromo-5-(difluoromethoxy)phenyl)methanamine
Methyl 3-(2-fluoroethyl)-5-oxopyrrolidine-3-carboxylate
Tert-butyl 3-(3-hydrazinylpropyl)piperidine-1-carboxylate
3-(2-Fluoroethyl)-5-oxopyrrolidine-3-carboxylic acid
4-Amino-4-(2-fluoroethyl)pyrrolidin-2-one
4-Amino-4-(2,2-difluoroethyl)pyrrolidin-2-one
Tert-butyl 3-(2,2-difluoroethyl)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

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