Chloroacetyl isocyanate

Names

[ CAS No. ]:
4461-30-7

[ Name ]:
Chloroacetyl isocyanate

[Synonym ]:
2-chloroacetyl isocyanate
EINECS 224-715-4
MFCD00002034

Chemical & Physical Properties

[ Density]:
1.403

[ Boiling Point ]:
50-55ºC (20 mmHg)

[ Melting Point ]:
25°C

[ Molecular Formula ]:
C₃H₂ClNO₂

[ Molecular Weight ]:
119.50600

[ Flash Point ]:
61ºC

[ Exact Mass ]:
118.97700

[ PSA ]:
46.50000

[ LogP ]:
0.08760

[ Appearance of Characters ]:
Liquid | Clear yellow

[ Index of Refraction ]:
1.463

[ Storage condition ]:
-20°C

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H314-H334

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C,T

[ Risk Phrases ]:
34-20/21/22-14-25

[ Safety Phrases ]:
8-45-36/37/39-26

[ RIDADR ]:
UN 3080

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2929109000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2-CHLORO-N-{[(3,4-DIMETHYLPHENYL)AMINO]CARBONYL}ACETAMIDE
n-chloroacetyl urethane
Methyl (chloroacetyl)carbamate
TNP 470
N-(Chloroacetyl)-N-(4-methylphenyl)urea
1-(2-chloroacetyl)-3-(4-chlorophenyl)urea
2-CHLORO-N-{[(4-METHOXYPHENYL)AMINO]CARBONYL}ACETAMIDE
1-(2-chloroacetyl)-3-o-tolylurea
N-{[(4-BROMOPHENYL)AMINO]CARBONYL}-2-CHLOROACETAMIDE
Acetamide,2-chloro-N-[[(1-methylethyl)amino]carbonyl]-

Customs

[ HS Code ]: 2929109000

[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues.

Org. Biomol. Chem. 3(11) , 2150-4, (2005)

A promising approach among the numerous efforts to cure cancer is the interruption of the tumour-induced formation of new blood vessels (angiogenesis). By suppressing angiogenesis with drugs, the tumo...

Synthesis of 4-azacyclopent-2-enones and 5, 5-dialkyl-4-azacyclopent-2-enones. Dauvergne J, et al.

Tetrahedron 60(11) , 2559-67, (2004)