NS-1643

[ Density]:
1.627g/cm3

[ Boiling Point ]:
342.311ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₀F₆N₂O₃

[ Molecular Weight ]:
380.24200

[ Flash Point ]:
160.824ºC

[ Exact Mass ]:
380.06000

[ PSA ]:
81.59000

[ LogP ]:
4.92540

[ Appearance of Characters ]:
white solid

[ Index of Refraction ]:
1.589

[ Storage condition ]:
-20℃

Click to get detail MSDS

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319

[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ RIDADR ]:
UN 2811 6.1 / PGIII

The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.

J. Pharmacol. Exp. Ther. , (2014)

Human ether-a-go-go-related gene (hERG) and KCNQ channels are two classes of voltage-gated potassium channels. Specific mutations have been identified that are causal for type II long QT (LQT2) syndro...

Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.

J. Neurosci. 36 , 2769-81, (2016)

DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine dioxygenase (TET) occurs abundantly in neurons of mammals. However, the in vivo causal link between TET dysregu...

Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.

Cell Death Dis. 4 , e652, (2013)

Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian cells including cardiac myocytes. hERG1 has recently been found to be ...

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