2-Bromo-5-fluoroanisole

Names

[ CAS No. ]:
450-88-4

[ Name ]:
2-Bromo-5-fluoroanisole

[Synonym ]:
MFCD04973752
Benzene, 1-bromo-4-fluoro-2-methoxy-
1-Bromo-4-fluoro-2-methoxybenzene
2-Bromo-5-fluoroanisole
FR DE CO1
2-Bromo-5-fluorophenyl methyl ether

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
187.9±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₆BrFO

[ Molecular Weight ]:
205.024

[ Flash Point ]:
80.2±6.0 °C

[ Exact Mass ]:
203.958603

[ PSA ]:
9.23000

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.519

[ Storage condition ]:
Room temperature.

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22;R36

[ Safety Phrases ]:
26-36/37/39

[ HS Code ]:
2909309090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Dimethyl sulfate
2-Bromo-5-fluorophenol
1-Bromo-2,4-difluorobenzene
Potassium methoxide
methyl iodide
Methanol
3-Fluoroanisole
5-Fluoro-2-nitroanisole
4-Fluoro-2-methoxyaniline
Formylpiperidine

DownStream

Anacetrapib
5-BROMO-4-METHOXY-1H-INDAZOLE
(4-Fluoro-2-methoxyphenyl)boronic acid
4-Fluoro-o-anisonitrile
4-fluoro-5-isopropyl-2-methoxyphenylboronic acid
4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2- methanol
1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone
1-Bromo-4-fluoro-5-isopropyl-2-methoxybenzene
3-bromo-6-fluoro-2-methoxybenzaldehyde
5-Bromo-2-fluoro-4-methoxybenzaldehyde

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%