3-(2-Fluorophenyl)acrylic acid

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Names

[ CAS No. ]:
451-69-4

[ Name ]:
3-(2-Fluorophenyl)acrylic acid

[Synonym ]:
3-(2-fluorophenyl)-2-propenoic acid
2-Propenoic acid, 3-(2-fluorophenyl)-, (2E)-
3-(2-Fluorophenyl)acrylic acid
(2E)-3-(2-Fluorophenyl)acrylic acid
2-fluoro-cinnamic acid
(2E)-3-(2-fluorophenyl)prop-2-enoic acid
3-(2-fluoro-phenyl)acrylic acid
TRANS-2-FLUOROCINNAMIC ACID
2-Fluor-zimtsaeure
MFCD00004370
EINECS 207-195-3
2-Fluorocinnamic acid
RARECHEM BK HC T305
o-fluoro-cinnamicaci
2-Fluorociamic acid
Cinnamic acid,o-fluoro
2-fluorincinnamic acid
O-FLUOROCINNAMIC ACID

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
281.6±15.0 °C at 760 mmHg

[ Melting Point ]:
178-180 °C(lit.)

[ Molecular Formula ]:
C9H7FO2

[ Molecular Weight ]:
166.149

[ Flash Point ]:
124.1±20.4 °C

[ Exact Mass ]:
166.043015

[ PSA ]:
37.30000

[ LogP ]:
2.47

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.591

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD9081000
CHEMICAL NAME :
Cinnamic acid, o-fluoro-
CAS REGISTRY NUMBER :
451-69-4
BEILSTEIN REFERENCE NO. :
1863963
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H7-F-O2
MOLECULAR WEIGHT :
166.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,285,1953

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GD9081000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Malonic acid
  • 2-Fluorobenzaldehyde
  • Ethanoic anhydride
  • 2-Propenoicacid, 3-(2-aminophenyl)-

DownStream

  • methyl 3-(2-fluorophenyl)propanoate
  • 5-Fluoro-1-indanone
  • ETHYL 2?FLUOROCINNAMATE
  • 3-(2-Fluorophenyl)propionic acid
  • 3-(2-Fluorophenyl)propanal
  • (E)-3-(2-FLUORO-PHENYL)-ACRYLOYL CHLORIDE
  • 3-Chloro-4-fluoro-1-benzothiophene-2-carbonyl chloride
  • 3-(2-Fluorophenyl)-1-propanol
  • ethyl 3-(2-fluorophenyl)propanoate
  • 3-(2-fluorophenyl)propanoyl chloride

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.

Bioorg. Med. Chem. Lett. 15(2) , 363-6, (2005)

Replacement of the morpholinyl moiety in (S,E)-N-[1-(3-morpholinophenyl)ethyl]-3-phenylacrylamide (1) with heteroaryl groups led to the identification of (S,E)-N-1-[3-(6-fluoropyridin-3-yl)phenyl]ethy...


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Related Compounds

  • (Z)-3-(2-fluorophenyl)acrylic acid
  • 3-(2-fluorophenyl)acrylic acid methyl ester
  • 3-(3-BROMO-2-FLUOROPHENYL)ACRYLIC ACID
  • (E)-3-(2-Bromo-5-fluorophenyl)acrylicacid
  • (2E)-3-(4-Chloro-2-fluorophenyl)acrylic acid
  • (2E)-3-(4-Amino-2-fluorophenyl)acrylic acid
  • 1-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]oxolane-2-carbonyl}-2-methylpyrrolidine-3-carboxylic acid
  • 1-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]furan-2-carbonyl}-2-methylpyrrolidine-3-carboxylic acid
  • 4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoro-2-methylpropanamido]oxolane-3-carboxylic acid
  • 1-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetyl}azepane-2-carboxylic acid
  • 2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}cyclohexane-1-carboxylic acid
  • 5-({[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolan-3-yl]formamido}methyl)furan-2-carboxylic acid
  • 2-({2-ethyl-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]butanamido}methyl)-2-methylbutanoic acid
  • 2-(1-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-2-methylbutanoyl}piperidin-3-yl)acetic acid
  • 2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid
  • 2-[N-ethyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylpropanamido]acetic acid
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