Ethoxzolamide

Suppliers

Names

[ CAS No. ]:
452-35-7

[ Name ]:
Ethoxzolamide

[Synonym ]:
Ethamide
6-ethoxy-1,3-benzothiazole-2-sulfonamide
Glaucotensil
Ethoxyzolamide
Ethoxazolamide
2-Benzothiazolesulfonamide,6-ethoxy
EINECS 207-199-5
MFCD00057089
Etoxzolamide
6-Ethoxy-2-benzothiazolesulfonamide
Cardrase
Diuretic C
6-ethoxybenzothiazole-2-sulphonamide

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Boiling Point ]:
464.9ºC at 760mmHg

[ Melting Point ]:
190-193ºC(lit.)

[ Molecular Formula ]:
C₉H₁₀N₂O₃S₂

[ Molecular Weight ]:
258.31700

[ Flash Point ]:
235ºC

[ Exact Mass ]:
258.01300

[ PSA ]:
118.90000

[ LogP ]:
3.12350

[ Vapour Pressure ]:
8.05E-09mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL6390000

CHEMICAL NAME :: 2-Benzothiazolesulfonamide, 6-ethoxy-

CAS REGISTRY NUMBER :: 452-35-7

BEILSTEIN REFERENCE NO. :: 0212240

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H10-N2-O3-S2

MOLECULAR WEIGHT :: 258.33

WISWESSER LINE NOTATION :: T56 BN DSJ CSZW GO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3300 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 1,51,1968

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DL6390000

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2-CYANO-6-HYDROXYBENZOTHIAZOLE
2-(6-Hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-ca rboxylic acid
L-LUCIFERIN
D-Luciferin
dehydroluciferin
(2-sulfamoyl-1,3-benzothiazol-6-yl) butanoate
(2-sulfamoyl-1,3-benzothiazol-6-yl) 2-phenylacetate
(2-sulfamoyl-1,3-benzothiazol-6-yl) cyclohexanecarboxylate
N-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfonyl]acetamide
6-ETHOXYBENZO[D]THIAZOLE-2-CARBONITRILE

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase.

PLoS ONE 6(11) , e27167, (2011)

Transport metabolons have been discussed between carbonic anhydrase II (CAII) and several membrane transporters. We have now studied different CA isoforms, expressed in Xenopus oocytes alone and toget...

Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes.

J. Physiol. 593 , 3533-47, (2015)

The regulation of H(+) i from cytosolic alkalosis has generally been attributed to the activity of Cl(-) -coupled acid loaders/base extruders in most cell types, including brain cells. The present stu...

Functional interaction between bicarbonate transporters and carbonic anhydrase modulates lactate uptake into mouse cardiomyocytes.

Pflugers Arch. 467 , 1469-80, (2015)

Blood-derived lactate is a precious energy substrate for the heart muscle. Lactate is transported into cardiomyocytes via monocarboxylate transporters (MCTs) together with H(+), which couples lactate ...