5-Chloro-2-Fluorotoluene

Names

[ CAS No. ]:
452-66-4

[ Name ]:
5-Chloro-2-Fluorotoluene

[Synonym ]:
4-Chloro-1-fluoro-2-methylbenzene
5-Chloro-2-Fluorotoluene
EINECS 207-204-0
Benzene, 4-chloro-1-fluoro-2-methyl-
MFCD00018504
4-Chlor-1-fluor-2-methylbenzol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
162.7±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₆ClF

[ Molecular Weight ]:
144.574

[ Flash Point ]:
52.5±7.3 °C

[ Exact Mass ]:
144.014206

[ LogP ]:
3.28

[ Vapour Pressure ]:
2.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.502

[ Storage condition ]:
Flammables area

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S16-S26-S36/37/39-S37/39

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Fluoro-2-methyl-4-nitrobenzene
2-Fluorotoluene
4-Fluoro-3-methylaniline

DownStream

5-Chloro-2-fluorobenzoyl chloride
5-Chloro-2-fluorobenzoic acid
4-Chloro-2-fluorobenzaldehyde
5-Chloro-2-fluorobenzaldehyde
5-Chloro-2-fluorobenzyl bromide

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Palladium-Catalyzed C(sp(3))-C(sp(2)) Cross-Coupling of (Trimethylsilyl)methyllithium with (Hetero)Aryl Halides.

Org. Lett. , (2015)

The palladium-catalyzed direct cross-coupling of a range of organic chlorides and bromides with the bifunctional C(sp(3))-(trimethylsilyl)methyllithium reagent is reported. The use of Pd-PEPPSI-IPent ...

Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides.

J. Med. Chem. 34 , 3098, (1991)

For several decades a tantalizing goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. Recent results from several researc...

Synthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: highly potent and long-lasting calcium antagonists.

Chem. Pharm. Bull. 40 , 2049, (1992)

New 1,4-dihydropyridine derivatives bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2,2-dimethyl-propyl ester were synthesized and their antihypertensive activities were ex...

4-Bromo-5-chloro-2-fluorotoluene
α-Bromo-5-chloro-2-fluorotoluene
5-Chloro-2-pentanol
5-chloro-2-methoxy-1,3-dimethylbenzene
5-chloro-2,2'-bithiophene
5-chloro-2-(cyclohexylamino)benzoic acid
6-(2-Ethylphenoxy)-3-pyridinecarboxylic acid
2-(2-Ethylphenoxy)-1-(piperazin-1-yl)propan-1-one
8-Chloro-5-methylchroman-4-amine
3-(2-Chloro-5-methylphenoxy)propan-1-amine
2-Chloro-6-(2-chloro-5-methylphenoxy)benzaldehyde
1-(4-Aminophenoxy)-3-pyrrolidin-1-ylpropan-2-ol
1-(4-Aminophenoxy)-3-(4-methylpiperazin-1-yl)propan-2-ol
1-(4-Amino-phenoxy)-3-piperidino-propan-2-ol
4-Bromo-2-(4-methylphenoxy)benzaldehyde
4-Bromo-2-(2-propoxyphenoxy)benzaldehyde

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.