4-Fluoro-2-methylaniline

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Names

[ CAS No. ]:
452-71-1

[ Name ]:
4-Fluoro-2-methylaniline

[Synonym ]:
4-F-2-MePhNH2
2-Amino-5-fluorotoluene
3-FLUORO-6-AMINOTOLUENE
2-Fluoro-o-toluidine
4-Fluoro-2-methylani
ZR DF B1
2-Methyl-4-fluoroaniline
Benzenamine, 4-fluoro-2-methyl-
6-Amino-3-fluorotoluene
EINECS 207-208-2
MFCD00007832
4-Fluoro-2-methylaniline
4-fluorotoluidine
o-Toluidine,4-fluoro
4-fluoro-2-methylphenylamine
4-Fluoro-2-methylbenzenamine
4-Fluoro-o-toluidine
2-amino-5-fluorotoluen

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
206.9±20.0 °C at 760 mmHg

[ Melting Point ]:
14ºC

[ Molecular Formula ]:
C₇H₈FN

[ Molecular Weight ]:
125.144

[ Flash Point ]:
87.8±0.0 °C

[ Exact Mass ]:
125.064079

[ PSA ]:
26.02000

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.542

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY0500000

CHEMICAL NAME :: Benzenamine, 4-fluoro-2-methyl-

CAS REGISTRY NUMBER :: 452-71-1

BEILSTEIN REFERENCE NO. :: 1931798

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H8-F-N

MOLECULAR WEIGHT :: 125.16

WISWESSER LINE NOTATION :: ZR DF B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2 umol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,317,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23/24/25;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ RTECS ]:
CY0500000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

(4-Fluoro-2-methylphenyl)-hydrazine
5-Fluoro-2-hydroxybenzoic acid
5-Fluoro-1H-indazole
5-Fluoro-2-methoxybenzoic acid
4-Fluoro-2-methylphenol
2-Bromo-4-fluoro-6-methylbenzonitrile
4-Fluoro-2-methylanisole
Carbanilic acid,4-fluoro-2-methyl-, isopropyl ester (8CI)
ethyl N-(4-fluoro-2-methyl-phenyl)carbamate
4-Fluoro-2-methylbenzaldehyde

Articles

SYNTHESIS OF SCHIFF BASES OF 7-METHOXY-2-[4-(METHYLSULFANYL) PHENYL]-1-BENZOFURAN-5-CARBOXALDEHYDE AND ANIMES AND HYDRAZIDE. Thorat BR, et al.

Heterocycl. Lett. 4(1) , 41-53, (2014)