4-Bromo-3-fluorotoluene

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Names

[ CAS No. ]:
452-74-4

[ Name ]:
4-Bromo-3-fluorotoluene

[Synonym ]:
4-bromo-3-fluoro-toluene
Benzene, 1-bromo-2-fluoro-4-methyl-
1-Bromo-2-fluoro-4-methylbenzene
4-BroMo-3-fluorotoluene 5GR
3-Fluoro-4-bromo-toluone
4-Bromo-3-fluorotoluene
4-Bromo-3-fluoro-1-methylbenzene
1-Bromo-2-fluoro-4-methyl-benzene
4-Brom-3-fluor-toluol
2-fluoro-4-methylbromobenzene
3-FLUORO-4-BROMO-TOLUENE
4-Bromo-3-flurotoluene
MFCD00040940

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
185.7±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H6BrF

[ Molecular Weight ]:
189.025

[ Flash Point ]:
68.6±16.6 °C

[ Exact Mass ]:
187.963684

[ LogP ]:
3.41

[ Vapour Pressure ]:
0.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.527

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S16

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Bromo-5-methylaniline
  • 4-Bromo-3-nitrotoluene
  • 2-Nitro-p-acetotoluidide
  • 1-Amino-2-nitro-4-methylbenzene
  • 3-Fluorotoluene
  • Carbon tetrachloride
  • Bromine

DownStream

  • 3-Methylchrysene
  • 2-Methylchrysene
  • (2-Fluoro-4-biphenyl)acetic Acid
  • 4-(Aminomethyl)-2-fluorobenzonitrile
  • 2-fluoro-4-methyl-aniline
  • (4-Bromo-3-fluorophenyl)acetonitrile
  • 2-fluoro-4-[hydroxy-(3-methylimidazol-4-yl)methyl]benzonitrile
  • 2-fluoro-4-(imidazol-1-ylmethyl)benzonitrile
  • TERT-BUTYL 4-CYANO-3-FLUOROBENZYLCARBAMATE
  • 2-Bromo-5-methylanisole

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates.

J. Med. Chem. 54 , 2293-306, (2011)

Poor blood-brain barrier penetration of nonsteroidal anti-inflammatory drugs (NSAIDs) has been blamed for the failure of the selective amyloid lowering agent (SALA) R-flurbiprofen in phase 3 clinical ...

Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

Bioorg. Med. Chem. Lett. 11(11) , 1411-5, (2001)

A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity ...

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

J. Med. Chem. 48 , 5705-20, (2005)

Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit beta-amyloid(1)(-)(42) (Abeta42) secretion, the most toxic component of the senile plaque...


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Related Compounds

  • 4-Bromo-3-fluorophenyl acetate
  • 4-bromo-3,5-dinitro-benzaldehyde
  • 4-bromo-3-hydroxy-6-methyl-2-nitro-benzoic acid
  • (4-bromo-3-methylbut-2-enyl)-tributylphosphanium,bromide
  • 4-Bromo-3-(1,3-dioxolan-2-yl)benzonitrile
  • 4-bromo-3-hydroxyisoindolin-1-one
  • rac-[(1R,3R)-2,2-dimethyl-3-(2-phenylpropan-2-yl)cyclopropyl]methanamine
  • 1-{Imidazo[1,2-a]pyridin-3-yl}-2,2-dimethylcyclopropane-1-carboxylic acid
  • tert-butyl N-(6-hydroxy-2,2-dimethylheptan-3-yl)carbamate
  • 1-Amino-2-methyl-1-(pyrimidin-5-yl)propan-2-ol
  • 3-Bromo-4-(2-isocyanatopropan-2-yl)pyridine
  • 2-(2-Isocyanatoethyl)imidazo[1,2-a]pyridine
  • 3-(1-Amino-2,2-dimethylcyclopropyl)benzonitrile
  • Ethyl 4-(1-ethynylcyclopropyl)piperidine-1-carboxylate
  • 3-[2-(Dimethylamino)-4-fluorophenyl]-1,1,1-trifluoropropan-2-one
  • 1-(1-ethyl-1H-pyrazol-3-yl)propan-2-ol