3-Fluoro-4-methylaniline

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Names

[ CAS No. ]:
452-77-7

[ Name ]:
3-Fluoro-4-methylaniline

[Synonym ]:
3-FLUORO-PARA-TOLUIDINE
3-Fluoro-4-methylaniline
3-fluoro-4-methyl-benzenamin
3-fluoro-4-methyl-aniline
3-fluoro-p-toluidin
4-Amino-2-fluorotoluene
ZR CF D1
EINECS 207-212-4
3-Fluoro-4-methylani
3-Fluoro-p-toluidine
2-fluoro-4-aminotoluene
4-methyl-3-fluoroaniline
Benzenamine, 3-fluoro-4-methyl-
3-Fluoro-4-methylbenzenamine
MFCD00007762

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
203.8±20.0 °C at 760 mmHg

[ Melting Point ]:
30-32 °C

[ Molecular Formula ]:
C₇H₈FN

[ Molecular Weight ]:
125.144

[ Flash Point ]:
88.9±0.0 °C

[ Exact Mass ]:
125.064079

[ PSA ]:
26.02000

[ LogP ]:
1.85

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.542

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU6825000

CHEMICAL NAME :: p-Toluidine, 3-fluoro-

CAS REGISTRY NUMBER :: 452-77-7

BEILSTEIN REFERENCE NO. :: 2715987

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H8-F-N

MOLECULAR WEIGHT :: 125.16

WISWESSER LINE NOTATION :: ZR CF D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 1300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P264-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S45-S36/37/39-S26-S36/37

[ RIDADR ]:
2811

[ RTECS ]:
XU6825000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2921430090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Fluoro-4-nitrotoluene
2-Nitrotoluene
3-fluoroaniline
Methyl fluoride
4-CHLORO-2-FLUORO-1-METHYLBENZENE

DownStream

2-Fluoro-4-methoxybenzoic acid
3-Fluoro-4-methylphenol
2-Fluoro-4-methoxy-1-methylbenzene
4-Amino-2-fluorobenzoic acid
3-Fluoro-4-methylbenzenethiol
2-Fluoro-4-isocyanato-1-methylbenzene
2-Bromo-5-fluoro-4-methylaniline
TERT-BUTYL 4-(BROMOMETHYL)-3-FLUOROPHENYLCARBAMATE
N-(3-Fluoro-4-methylphenyl)acetamide
tert-butyl N-(3-fluoro-4-methylphenyl)carbamate

Customs

[ HS Code ]: 2921430090

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Preconcentration of aniline derivatives from aqueous solutions using micellar-enhanced ultrafiltration.

Analyst 118(1) , 23-27, (1993)

N-Ethyl-3-fluoro-4-methylaniline
2,6-Dibromo-3-fluoro-4-methylaniline
N-diethoxyphosphoryl-3-fluoro-4-methylaniline
N-diphenoxyphosphoryl-3-fluoro-4-methylaniline
3-FLUORO-4-IODO-2-METHYLANILINE
3-Fluoro-4-methoxy-2-methylaniline
1-Chloro-1-(3,5-diethoxyphenyl)propan-2-one
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
Cyclopropyl(4-methylphenyl)methanesulfonyl fluoride
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-(2,2-difluoro-1,3-dioxaindan-5-yl)propanoate