Velcorin

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Names

[ CAS No. ]:
4525-33-1

[ Name ]:
Velcorin

[Synonym ]:
Velcorin
Carbonic acid, methoxycarbonyl methyl ester
EINECS 224-859-8
MFCD00008419
dicarbonic acid dimethyl ester
methoxycarbonyl methyl carbonate
Dimethyl pyrocarbonate
DMPC Dimethyl pyrocarbonate Pyrocarbonic acid dimethyl ester
Dimethyl dicarbonate

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
171.4±0.0 °C at 760 mmHg

[ Melting Point ]:
15-17ºC

[ Molecular Formula ]:
C4H6O5

[ Molecular Weight ]:
134.087

[ Flash Point ]:
80.0±0.0 °C

[ Exact Mass ]:
134.021530

[ PSA ]:
61.83000

[ LogP ]:
0.42

[ Vapour Pressure ]:
1.4±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.395

[ Water Solubility ]:
35g/l (decomposition)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HT0362500
CHEMICAL NAME :
Dicarbonic acid, dimethyl ester
CAS REGISTRY NUMBER :
4525-33-1
LAST UPDATED :
199806
DATA ITEMS CITED :
3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
711 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545284 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/m3/6H/5D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545284

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H312-H314-H330

[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R21/22

[ Safety Phrases ]:
18-26-28-36/37/39-38-45

[ RIDADR ]:
UN 2927 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
HT0362500

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2920909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl chloroformate

DownStream

  • Methyl 4-acetylbenzoate
  • Boc-Pro-OMe
  • Methyl cyclohexanoate
  • Methyl 3-phenylpropanoate
  • Methyl 4-oxopentanoate
  • Carbon dioxide
  • Dimethyl Carbonate
  • Methyl 4-hydroxybenzoate

Customs

[ HS Code ]: 2920909090

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Influence of the lipid membrane environment on structure and activity of the outer membrane protein Ail from Yersinia pestis.

Biochim. Biophys. Acta 1848(2) , 712-20, (2014)

The surrounding environment has significant consequences for the structural and functional properties of membrane proteins. While native structure and function can be reconstituted in lipid bilayer me...

Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides.

Biophys. Chem. 196 , 40-52, (2014)

Plasticins (PTC) are dermaseptin-related antimicrobial peptides characterized by a large number of leucine and glycine residues arranged in GXXXG motifs that are often described to promote helix assoc...

Comparison of [corrected] actin- and glass-supported phospholipid bilayer diffusion coefficients.

Biophys. J. 108(8) , 1946-53, (2015)

The formation of biomimetic lipid membranes has the potential to provide insights into cellular lipid membrane dynamics. The construction of such membranes necessitates not only the utilization of app...


More Articles

Related Compounds

  • 2-Chloro-N-[2-(4-methylphenyl)ethyl]-N-(oxolan-2-ylmethyl)acetamide
  • 2-Chloro-1-[2-(5-chlorothiophen-2-yl)morpholin-4-yl]propan-1-one
  • 2-Chloro-N-[4-chloro-3-(5-cyclopropyltetrazol-1-yl)phenyl]acetamide
  • 2-Chloro-N-[[5-chloro-2-(difluoromethoxy)phenyl]methyl]acetamide
  • 2-chloro-N-{[4-(3,4-difluorophenoxy)pyridin-2-yl]methyl}acetamide
  • 2-Chloro-N-(6-fluoro-2-methyl-2,3-dihydro-1H-inden-1-yl)acetamide
  • 4-(2-chloroacetyl)-octahydro-2H-1lambda6,4-benzothiazine-1,1-dione
  • 2-Chloro-1-[3-(2-hydroxy-2-thiophen-2-ylethyl)morpholin-4-yl]ethanone
  • 2-Chloro-N-(6-fluoro-2-methyl-2,3-dihydro-1H-inden-1-yl)propanamide
  • N-[1-(2-Chloroacetyl)piperidin-3-yl]-1-benzofuran-2-carboxamide
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