Piperilate

Names

[ Name ]:
Piperilate

[Synonym ]:
Pipethanatum [INN-Latin]
2-(1-Piperidino)ethyl benzilate
Pipetanato [INN-Spanish]
Piperilate
Benzilsaeure-(2-piperidino-aethylester)
pipethanate
BENZILIC ACID,2-PIPERIDINOETHYL ESTER
Benzilsaeure-<2-piperidino-ethylester>
1-Piperidineethanol benzilate

Chemical & Physical Properties

[ Density]:
1.155 g/cm3

[ Boiling Point ]:
444.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₅NO₃

[ Molecular Weight ]:
339.42800

[ Flash Point ]:
222.4ºC

[ Exact Mass ]:
339.18300

[ PSA ]:
49.77000

[ LogP ]:
2.88950

[ Index of Refraction ]:
1.574

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD4198000

CHEMICAL NAME :: Benzilic acid, 2-piperidinoethyl ester

CAS REGISTRY NUMBER :: 4546-39-8

BEILSTEIN REFERENCE NO. :: 0385167

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H25-N-O3

MOLECULAR WEIGHT :: 339.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 162 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-(2-chlorethyl)piperidinhydrochlorid
N-Chloroethyl piperidine
Benzilic acid
2-Piperidinoethanol
Benzeneacetic acid, a-hydroxy-a-phenyl-, ethyl ester

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Piperilate ethobromide
Piperilate hydrochloride
1-ethyl-N-(furan-2-ylmethyl)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide
N-{3-[(4-methoxyphenyl)sulfonyl]-4,5-dimethyl-1-propyl-1H-pyrrol-2-yl}benzamide
N-[cyano(phenyl)methyl]-4-phenoxybenzamide
(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl 2H-chromene-3-carboxylate
2-((1-(4-chlorophenyl)-5-(p-tolyl)-1H-imidazol-2-yl)thio)-1-(indolin-1-yl)ethanone
2-hydroxyethyl 3-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazole-4-carboxylate
N-(6-Methyl-2-pyridinyl)-2-quinoxalinamine
N-[4-Fluoro-5-(3-methyl-1-piperazinyl)-2-nitrophenyl]methanesulfonamide
1-(6,7-Dihydro-[1,4]dioxino[2',3':4,5]benzo[1,2-d]thiazol-2-yl)-3-isopropylurea
2-[2-(azepan-1-yl)-2-oxoethyl]-2H,3H,5H,6H,7H,8H,9H-[1,2,4]triazolo[4,3-a]azepin-3-one

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