4-(Trifluoromethyl)benzoic acid

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Names

[ CAS No. ]:
455-24-3

[ Name ]:
4-(Trifluoromethyl)benzoic acid

[Synonym ]:
4-(Trifluoromethyl)benzoic acid
P-CARBOXYBENZOTRIFLUORIDE
a,a,a-trifluoro-p-toluic acid
Benzoic acid, 4-(trifluoromethyl)-
4-TRIFLUOROMETHYLBENZOIC ACID
α,α,α-trifluoro-p-toluic acid
p-Trifluoromethylbenzoic acid
PTF-BOA
QVR DXFFF
4-Carboxybenzotrifluoride
para-trifluoromethylbenzoic acid
p-(Trifluoromethyl)benzoic acid
p-CF3-benzoic acid
EINECS 207-242-8
MFCD00002562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
243.2±40.0 °C at 760 mmHg

[ Melting Point ]:
219-220 °C(lit.)

[ Molecular Formula ]:
C₈H₅F₃O₂

[ Molecular Weight ]:
190.12

[ Flash Point ]:
100.9±27.3 °C

[ Exact Mass ]:
190.024170

[ PSA ]:
37.30000

[ LogP ]:
3.10

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.475

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29163900

Precursor & DownStream

Precursor

Carbon dioxide
4-trifluoromethylbenzeneboronic acid neopentyl glycol ester
4-Bromobenzotrifluoride
4-(Trifluoromethyl)benzaldehyde
carbon monoxide
4-Chlorobenzotrifluoride
4-(Trifluoromethyl)Mandelic Acid
4-Iodobenzotrifluoride
4-(TRIFLUOROMETHYL)PHENYL TRIFLUOROMETHANESULFONATE
Methanol

DownStream

4-Trifluoromethylsalicylic acid
4-(Trifluoromethyl)benzoyl chloride
(4-(Trifluoromethyl)phenyl)methanol
ETHYL 4-(TRIFLUOROMETHYL)BENZOATE
2-Nitro-4-trifluoromethyl-benzoic acid
3-Nitro-4-(trifluoromethyl)benzoic acid
4-(Trifluoromethyl)benzonitrile
4-(TRIFLUOROMETHYL)BENZHYDRAZIDE
4-(Trifluoromethyl)benzaldehyde
4-(Trifluoromethyl)benzyl chloride

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Bacterial metabolism of side chain fluorinated aromatics: cometabolism of 4-trifluoromethyl(TFM)-benzoate by 4-isopropylbenzoate grown Pseudomonas putida JT strains.

Arch. Microbiol. 149(3) , 198-206, (1988)

Enzymes of the p-cymene pathway in Pseudomonas putida strains cometabolized the intermediate analogue 4-trifluoromethyl(TFM)benzoate. Three products, 4-TFM-2,3-dihydro-2,3-dihydroxybenzoate, 4-TFM-2,3...

Studies on the metabolism of fluorinated xenobiotics in the rat using 19F-NMR and 1H-NMR spectroscopy.

J. Pharm. Biomed. Anal. 8(8-12) , 939-44, (1990)

Determination of the equilibrium distibution between alcohol and aldehyde substrates when bound to horse liver alcohol dehydrogenase using magnetic resonance.

Biochemistry 19(24) , 5486-93, (1980)

The interactions of horse liver alcohol dehydrogenase (LADH) with the rho-trifluoromethyl derivatives of benzyl alcohol, benzaldehyde, and benzoic acid have been investigated by use of 19F nuclear mag...