4-Fluorophenacyl chloride

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Names

[ CAS No. ]:
456-04-2

[ Name ]:
4-Fluorophenacyl chloride

[Synonym ]:
α-Chloro-p-fluoroacetophenone
G1VR DF
α-Chloro-para-fluoroacetophenone
2-chloro-4'-fluoro-acetophenone
α-Chloro-4'-fluoroacetophenone
A-CHLORO-4-FLUOROACETOPHENONE
p-Fluorophenacyl chloride
Fluorophenacylchloride
MFCD00011652
2-Chloro-4′-fluoroacetophenone
Ethanone, 2-chloro-1-(4-fluorophenyl)-
4-Fluorchloracetophenone
2-Chloro-1-(4-fluorophenyl)ethan-1-one
Ethanone, 2-chloro-1-(4-fluorophenyl)- (9CI)
2-Chloro-4'-fluoroacetophenone
Acetophenone, α-chloro-4'-fluoro-
EINECS 207-256-4
2-Chloro-4‘-fluoroacetophenone
Acetophenone, 2-chloro-4'-fluoro-
2-Chloro-4'-fluoroac
4-Fluorophenacyl chloride
2-Chloro-1-(4-fluorophenyl)ethanone
ω-Chloro-4'-fluoroacetophenone

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
247.0±15.0 °C at 760 mmHg

[ Melting Point ]:
47-50 °C(lit.)

[ Molecular Formula ]:
C8H6ClFO

[ Molecular Weight ]:
172.584

[ Flash Point ]:
103.2±20.4 °C

[ Exact Mass ]:
172.009125

[ PSA ]:
17.07000

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.514

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AM6550000
CHEMICAL NAME :
Acetophenone, 2-chloro-4'-fluoro-
CAS REGISTRY NUMBER :
456-04-2
BEILSTEIN REFERENCE NO. :
0637860
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H6-Cl-F-O
MOLECULAR WEIGHT :
172.59
WISWESSER LINE NOTATION :
G1VR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05172

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
T:Toxic;Xi:Irritant;

[ Risk Phrases ]:
R23/25;R34;R36/37/38

[ Safety Phrases ]:
S26-S28-S45-S36/37/39

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
AM6550000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2914700090

Precursor & DownStream

Precursor

  • 4'-Fluoroacetophenone
  • Fluorobenzene
  • Chloroacetyl chloride
  • p-Fluorophenacyl bromide
  • 3-(5-chloropyrid-2-yl)-4-(4-fluorophenyl)-thiazolidine-2-thione
  • diazomethane
  • N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride
  • (Trimethylsilyl)diazomethane

DownStream

  • 2-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
  • 1,2-Bis(4-fluorophenyl)ethanone
  • 1-Isopropyl-3-(4-fluorophenyl)-indole
  • [2-(4-fluorophenyl)-2-oxoethyl] acetate
  • 4-(4-Fluorophenyl)-2-methylthiazole
  • 2-FORMYL-3-(4-FLUOROPHENYL)-1-N-METHYLINDOLE
  • 4-Fluorobenzoylacetonitrile
  • 4-Fluorophenylacetone
  • 4'-Fluoro-2-hydroxyacetophenone
  • 1-(4-Fluorophenyl)-2-methoxyethan-1-one

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones.

Chem. Res. Toxicol. 20(1) , 149-54, (2007)

S-(Phenacyl)glutathione reductase (SPG-R) plays a significant role in the biotransformation of reactive alpha-haloketones to nontoxic acetophenones. Comparison of the apparent subunit size, amino acid...

Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.

Bioorg. Med. Chem. 17(4) , 1716-23, (2009)

Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous re...

Allergic contact dermatitis from 3-(alpha-methoxy) methylenebenzofuran-2(3H)-one (MBF) and alpha-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.

Contact Dermatitis 34(6) , 434-5, (1996)


More Articles

Related Compounds

  • 4-FLUOROPHENACYL THIOCYANATE
  • 1-(4-fluorophenyl)-2-thieno[3,2-c]pyridin-5-ium-5-ylethanone,chloride
  • 2-CHLORO-4-FLUOROPHENACYL BROMIDE
  • 2-Bromo-4-fluorophenacyl bromide
  • acetyl-p-fluorophenyltriphenylarsonium bromide
  • 2-[2-(4-fluorophenyl)-2-oxoethyl]cyclohexan-1-one
  • 3-[(Tert-butoxy)carbonyl]-5-(propan-2-yl)-3-azabicyclo[3.1.1]heptane-1-carboxylic acid
  • 2-Cyclopropyl-6-methoxy-[1,2,4]triazolo[1,5-a]pyrimidin-5-ol
  • 2-Methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-5-ol
  • Tert-butyl 1-(hydroxymethyl)-4-phenyl-2-azabicyclo[2.1.1]hexane-2-carboxylate
  • 2-{2-Ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl}ethan-1-ol
  • 2-{3-Iodo-2-methylpyrazolo[1,5-a]pyrimidin-6-yl}ethan-1-ol
  • 2-[2-(Propan-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl]ethan-1-ol
  • 7-(Thiophen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-5-ol
  • 6-Methoxy-2-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-5-ol
  • 2-methyl-5-(1-methyl-1H-pyrazol-5-yl)thieno[3,2-b]pyridin-7-amine
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