GITOXIN

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Names

[ CAS No. ]:
4562-36-1

[ Name ]:
GITOXIN

[Synonym ]:
Gitoksin
Anhydrogitalin
gitoxigenin-tridigitoxosid
Gitoxin (50 mg)
GINSENOSIDES KIT
bigitalin
GITOXIN

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
932ºC at 760 mmHg

[ Melting Point ]:
265ºC

[ Molecular Formula ]:
C₄₁H₆₄O₁₄

[ Molecular Weight ]:
780.94

[ Flash Point ]:
278.6ºC

[ Exact Mass ]:
780.43000

[ PSA ]:
203.06000

[ LogP ]:
2.21810

[ Index of Refraction ]:
1.602

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ0525000

CHEMICAL NAME :: Gitoxin

CAS REGISTRY NUMBER :: 4562-36-1

BEILSTEIN REFERENCE NO. :: 0077015

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C41-H64-O14

MOLECULAR WEIGHT :: 781.05

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 GQ IQ F- DT5OV EHJ& OO- FT6OTJ B1 DQ CO- FT6OTJ B1 DQ CO- FT6OTJ B1 CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 590 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 8,85,1970

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 222 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,364,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4400 ug/kg

TOXIC EFFECTS :: Cardiac - cardiomyopathy including infarction Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 155,251,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 1210 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 11,613,1963 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,183,1963

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H310 + H330

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P260-P262-P280-P302 + P352 + P310-P304 + P340 + P310

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
26/27/28

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 2811

[ RTECS ]:
LZ0525000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29389090

Precursor & DownStream

Precursor

DownStream

gitoxigenin 3-acetate
D-ribo-Hexose,2,6-dideoxy-
Gitoxigenin
16-O-acetylgitoxin

Articles

A new alternative in the field of cardiac glycosides: gitoxin.

J. Pharm. Belg. 41 , 39-53, (1986)

ACETYLGITOXIN,16
16-acetylgitoxin
16-acetylgitoxin
16-Formylgitoxin
16-Formylgitoxin
16-Formylgitoxin
1-[3-Amino-4-(trifluoromethyl)piperidin-1-yl]-4-(2,5-dimethylthiophen-3-yl)butan-1-one hydrochloride
[1-(2,3-Dihydro-1-benzofuran-7-yl)-4,4-difluorocyclohexyl]methanamine
1-[4-(Aminomethyl)-4-phenylpiperidin-1-yl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)ethanone;hydrochloride
1-[1-({2,3-Dihydrospiro[1-benzopyran-4,1'-cyclopropan]-3'-yl}carbonyl)-4-phenylpiperidin-4-yl]methanamine hydrochloride
Tert-butyl 4-{3-[(fluorosulfonyl)methyl]-5-iodo-2-methylphenyl}piperazine-1-carboxylate
Tert-butyl 4-{[5-(fluorosulfonyl)-3-iodo-2-methylphenyl]methyl}piperazine-1-carboxylate
tert-butyl 2-[5-azido-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2-methylphenyl]acetate
tert-butyl 2-[3-azido-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-4-methylphenyl]acetate
methyl 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2-methyl-5-(piperazin-1-yl)phenyl]acetate
methyl 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-4-methyl-5-(piperazin-1-yl)phenyl]acetate

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