3-Fluoro-4-hydroxyphenylacetic acid

Names

[ CAS No. ]:
458-09-3

[ Name ]:
3-Fluoro-4-hydroxyphenylacetic acid

[Synonym ]:
2-(3-fluoro-4-hydroxyphenyl)acetic acid
3-Fluoro-4-hydroxyphenylacetic acid
EINECS 207-275-8
MFCD00004348

Chemical & Physical Properties

[ Density]:
1.423 g/cm3

[ Boiling Point ]:
320.3ºC at 760 mmHg

[ Melting Point ]:
132-134 °C(lit.)

[ Molecular Formula ]:
C₈H₇FO₃

[ Molecular Weight ]:
170.13800

[ Flash Point ]:
147.5ºC

[ Exact Mass ]:
170.03800

[ PSA ]:
57.53000

[ LogP ]:
1.15840

[ Vapour Pressure ]:
0.000133mmHg at 25°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(3-Fluoro-4-methoxyphenyl)acetic acid
3-Fluoro-4-methoxybenzyl cyanide
3-Fluoro-4-hydroxymandelic acid
2-Fluoroanisole
3'-Fluoro-4'-hydroxyacetophenone
3-Fluoro-4-methoxybenzylchloride
2-Fluorophenol
Ethyl 3-fluoro-4-methoxybenzoylformate
2-(3-fluoro-4-methoxyphenyl)-2-oxoacetic acid
Pyridine chlorhydrate

DownStream

methyl 2-(4-cyano-3-fluorophenyl)acetate
Benzeneethanol,3-fluoro-4-hydroxy-

Articles

An in vivo microdialysis study of striatal 6-[18F]fluoro-L-m-tyrosine metabolism.

Neurochem. Res. 23(4) , 513-7, (1998)

In vivo brain microdialysis was used to monitor 6-[18F]fluoro-L-m-tyrosine (FMT) uptake and metabolism in the striatum of conscious freely moving rats for 3 hours after FMT injection (25 mg/kg, i.v.)....

3-Fluoro-4-methoxybenzoic acid
3-Fluoro-4-hydroxybenzoic acid
3-Fluoro-4-nitrobenzenesulfonic acid
3-Fluoro-4-morpholinophenylboronic Acid
3-Fluoro-4-hydroxymandelic acid
3-Fluoro-4-nitrobenzoic acid
N-[(3-methoxyphenyl)methyl]-9-[(oxolan-2-yl)methyl]-9H-purin-6-amine
1-[4-(6-Cyclopropyl-1,8-naphthyridin-2-yl)piperidin-1-yl]-2-(pyridin-3-yl)ethan-1-one
6-(Difluoromethyl)-2-{4-[6-(methylsulfanyl)-1,3-benzothiazol-2-yl]piperazin-1-yl}-3,4-dihydropyrimidin-4-one
1-(Tert-butyl) 4-methyl 4-((6-bromopyridin-2-yl)methyl)-2-methylpiperidine-1,4-dicarboxylate
2-(4-{5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperazin-1-yl)-4-(pyridin-2-yl)pyrimidine
2-(4-{3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperazin-1-yl)-4-(pyridin-4-yl)pyrimidine
2-[4-(7-Chloro-4-methyl-1,3-benzothiazol-2-yl)piperazin-1-yl]-6-(difluoromethyl)-3,4-dihydropyrimidin-4-one
4-methyl-2-{4-[(1-methyl-1H-1,2,4-triazol-5-yl)methyl]piperazin-1-yl}-6-(pyrrolidin-1-yl)pyrimidine
4-{4-[(1-methyl-1H-1,2,4-triazol-5-yl)methyl]piperazin-1-yl}-2-(pyrrolidin-1-yl)pyrimidine
6-Methyl-6-nitro-1,4-dipropyl-1,4-diazepane

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