Ethyl fluoroacetate

Suppliers

Names

[ CAS No. ]:
459-72-3

[ Name ]:
Ethyl fluoroacetate

[Synonym ]:
Acetic acid, 2-fluoro-, ethyl ester
Ethyl fluoroacetate
EINECS 207-297-8
Ethyl 2-fluoroacetate
MFCD00000450
Fluoroacetic Acid Ethyl Ester

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
118.0±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H7FO2

[ Molecular Weight ]:
106.096

[ Flash Point ]:
30.0±0.0 °C

[ Exact Mass ]:
106.043007

[ PSA ]:
26.30000

[ LogP ]:
0.37

[ Vapour Pressure ]:
17.0±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.354

[ Water Solubility ]:
DECOMPOSES

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH7175000
CHEMICAL NAME :
Acetic acid, fluoro-, ethyl ester
CAS REGISTRY NUMBER :
459-72-3
BEILSTEIN REFERENCE NO. :
1743761
LAST UPDATED :
199709
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H7-F-O2
MOLECULAR WEIGHT :
106.11
WISWESSER LINE NOTATION :
F1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
11FYAN "Fluorine Chemistry, Volume III. Biological Effects of Organic Fluorides," Simons, J.H., ed., New York, Academic Press, Inc., 1963 Volume(issue)/page/year: 3,59,1963 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 48,225,1951

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H300-H400

[ Precautionary Statements ]:
P264-P273-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R10;R26/27/28

[ Safety Phrases ]:
S13-S36/37/39-S45-S28A-S16

[ RIDADR ]:
UN 2929 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
AH7175000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
29159080

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl iodofluoroacetate
  • octene
  • rubidium trifluoromethoxylate
  • ethyl 2-bromoacetate
  • 1-Hexen-5-one
  • N-(2-ethylphenyl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide
  • Methyl vinyl ketone
  • Ethyl acrylate TOP1 supplier
  • EDA
  • acetyl fluoride

DownStream

  • 2-Propenoic acid,2-fluoro-3-phenyl-
  • Ethyl trifluoroacetoacetate
  • ETHYL CHLOROFLUOROACETATE
  • 1,2,3-triethyl (E)-3-fluoroprop-1-ene-1,2,3-tricarboxylate
  • 1-fluoro-3-phenylpropan-2-one
  • Ethanone, 2-fluoro-1-[2-[(methoxymethyl)thio]phenyl]- (9CI)
  • Trifluoroacetyl fluoride
  • 1,2,2,2-tetrafluoroethyl 2,2,2-trifluoroacetate
  • 1,1,2,2,2-pentafluoroethyl 2,2,2-trifluoroacetate
  • 2-fluoro-N'-phenylacetohydrazide

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis and pharmacological evaluation of enantiomerically pure 4-deoxy-4-fluoromuscarines.

J. Med. Chem. 35(17) , 3102-10, (1992)

Four isomers of [(4-fluoro-5-methyl-tetrahydrofuran-2-yl)methyl]trimethylammonium iodide (4-deoxy-4-fluoro-muscarines) were prepared in enantiomerically and diastereomerically pure form from (S)-(-)-m...

A Convenient Synthesis of Ethyl(Diethoxyphosphoryl) fluoroacetate from Ethyl Fluoroacetate. Elkik E and Imbeaux M.

Synthesis 1989(11) , 861-62, (1989)

Reactivity of ethyl acetate and its derivatives toward ammonolysis: ramifications for ammonolysis-based microencapsulation process. Chung Y, et al.

Polym. Adv. Technol. 20(10) , 785-94, (2009)


More Articles

Related Compounds

  • ethyl (4-bromophenoxy)fluoroacetate
  • ethyl 2-cyclopentylidene-2-fluoroacetate
  • ethyl 2-cyano-2-fluoroacetate
  • ethyl 2-ethylsulfanyl-2-fluoroacetate
  • ethyl 2-cyclohexylidene-2-fluoroacetate
  • ethyl 2-azido-2-ethylsulfanyl-2-fluoroacetate
  • N-(2-{2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)but-2-ynamide
  • (E)-N-[2-(3-Chloro-N-methylanilino)ethyl]-4-(dimethylamino)-N-methylbut-2-enamide
  • N-[2-(3-Chloro-N-methylanilino)ethyl]-N-methylbut-2-ynamide
  • (2E)-4-(dimethylamino)-N-[2-(3-hydroxyphenyl)-1-phenylethyl]but-2-enamide
  • 2-Chloro-N-[1-(4-chlorophenyl)-1-hydroxybutan-2-yl]acetamide
  • (2E)-4-(dimethylamino)-N-{1-[(5-fluorothiophen-2-yl)methyl]piperidin-4-yl}but-2-enamide
  • N-[1-[(5-Fluorothiophen-2-yl)methyl]piperidin-4-yl]but-2-ynamide
  • N-[(2-Cyclopentylpyrazol-3-yl)methyl]but-2-ynamide
  • N-[1-(4-Fluorophenyl)-3-morpholin-4-ylpropyl]but-2-ynamide
  • 2-(but-2-ynamido)-N-[(2-fluorophenyl)methyl]-N-methylpentanamide
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