3-chloro-1,1,1-trifluoropropane

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Names

[ CAS No. ]:
460-35-5

[ Name ]:
3-chloro-1,1,1-trifluoropropane

[Synonym ]:
EINECS 207-307-0
3-chloro-1,1,1-trifluoropropane
1,1,1-Trifluoro-3-chloropropane
Propane, 3-chloro-1,1,1-trifluoro-
HCFC-253fb
MFCD00069094

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
44.1±8.0 °C at 760 mmHg

[ Melting Point ]:
-106.2℃

[ Molecular Formula ]:
C3H4ClF3

[ Molecular Weight ]:
132.512

[ Flash Point ]:
-6.8±10.4 °C

[ Exact Mass ]:
131.995361

[ LogP ]:
1.55

[ Vapour Pressure ]:
380.2±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.324

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX6200000
CHEMICAL NAME :
Propane, 3-chloro-1,1,1-trifluoro-
CAS REGISTRY NUMBER :
460-35-5
BEILSTEIN REFERENCE NO. :
1734941
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C3-H4-Cl-F3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,115,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 28(12),9,1963
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,115,1982
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2300 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,115,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1062 mg/kg/30W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 28(12),9,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1062 mg/kg/30W-I
TOXIC EFFECTS :
Blood - change in clotting factors Blood - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 28(12),9,1963

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
22-36

[ Safety Phrases ]:
23-24/25-26

[ HS Code ]:
2903791090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • chlorotrifluoromethane
  • 1,1,1-trifluoropropane
  • 1,1,1,3-Tetrachloropropane
  • 2,3-Dichloro-1,1,1-trifluoropropane
  • 3,3,3-Trifluoropropene
  • 3-Chloropropionic Acid
  • 1,3-Dichloro-1,1-difluoropropane
  • 1,1,1-Trifluoro-3-iodopropane
  • Trifluorostibine
  • Hydrochloric acid

DownStream

  • 3,3,3-Trifluoro-1-propanamine
  • 1,2-Dibromo-3,3,3-trifluoropropane
  • 3,3-Dichloro-1,1,1-trifluoropropane
  • 1,1,1-trichloro-3,3,3-trifluoropropane
  • 3,3,3-Trifluoropropene
  • 3,3,3-Trifluoropropanol
  • chloro-tris(3,3,3-trifluoropropyl)silane
  • methyl(3,3,3-trifluoropropyl)silane
  • 1,1,1-trifluoropropane
  • 3-bromo-3-chloro-1,1,1-trifluoropropane

Customs

[ HS Code ]: 2903791090

[ Summary ]:
2903791090 halogenated derivatives of methane, ethane or propane (hcfcs)only with fluorine and chlorine。supervision conditions:14xy(import license,export license,export license,export license)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Related Compounds

  • 3-bromo-3-chloro-1,1,1-trifluoropropane
  • 2-bromo-3-chloro-1,1,1-trifluoropropane
  • 3-Chloro-1,1,1-trifluoro-3-phenylpropane
  • 3-Chloro-2-iodo-1,1,1-trifluoropropane
  • 3-Chloro-2-(trifluoromethyl)-2-iodo-1,1,1-trifluoropropane
  • [(3-chloro-1,1,1-trifluoropropan-2-yl)disulfanyl]methylbenzene